Pubblicazioni

Autori:

Roccaforte, Vincenzo; Sabbatini, Giovanni; Panella, Rossella; Daves, Massimo; Formenti, Paolo; Gotti, Miriam; Galimberti, Andrea; Spreafico, Marta; Piccin, Andrea; Lippi, Giuseppe; Pezzi, Angelo; Pastori, Stefano

Titolo:

The potential role of leukocytes cell population data (CPD) for diagnosing sepsis in adult patients admitted to the intensive care unit

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Clinical Chemistry and Laboratory Medicine

ISSN Rivista:

1434-6621

N° Volume:

63

Numero o Fascicolo:

5

Editore:

Walter De Gruyter

Intervallo pagine:

1031-1042

Parole chiave:

Sysmex, cell population data (CPD), markers sepsis, sepsis

Breve descrizione dei contenuti:

Objectives: The aim of the study was to evaluate the predictive value of cell population data (CPD) parameters in comparison with procalcitonin (PCT) and C-reactive protein (CRP) for an early diagnosis of sepsis in intensive care unit (ICU). The effect of renal function on CPD, PCT and CRP, in septic and non-septic patients was also investigated. Methods: This is a retrospective, observational and single-center study, performed with data collected from patients consecutively admitted to the ICU of the Edoardo Bassini Hospital in Milan. Patients were divided in septic and non-septic according to Sepsis-III criteria. The control group was formed by critically ill patients without sepsis. Patients with sepsis were further divided in patients with sepsis and patients with septic shock. Results: A significant difference between septic and non-septic patients was found for neutrophils complexity (NE-SSC), neutrophils fluorescence intensity (NE-SFL), width of dispersion of neutrophils fluorescence (NE-WY), monocytes complexity (MO-X), monocytes fluorescence intensity (MO-Y), PCT and CRP parameters. PCT, neutrophils sixe (NE-FSC), NE-WY, width of dispersion of neutrophils size (NE-WZ) and MO-X discriminated sepsis and septic-shock patients. CPD parameters were not influenced by renal function. CPD, PCT and CRP had a heterogeneous diagnostic performance efficiency in the prediction of sepsis. Overall, NE-SSC, NE-SFL, width of dispersion of neutrophils complexity (NE-WX), MO-X, MO-Y, PCT and CRP displayed the best diagnostic performance for sepsis. Conclusions: This study suggested that some CPD parameters (i.e., NE-SFL and MO-X) might provide useful information for diagnosis and management of sepsis.

Pagina Web:

https://www.degruyter.com/document/doi/10.1515/cclm-2024-1202/html

Id prodotto:

144044

Handle IRIS:

11562/1152067

ultima modifica:

23 aprile 2025

Citazione bibliografica:

Roccaforte, Vincenzo; Sabbatini, Giovanni; Panella, Rossella; Daves, Massimo; Formenti, Paolo; Gotti, Miriam; Galimberti, Andrea; Spreafico, Marta; Piccin, Andrea; Lippi, Giuseppe; Pezzi, Angelo; Pastori, Stefano, The potential role of leukocytes cell population data (CPD) for diagnosing sepsis in adult patients admitted to the intensive care unit «Clinical Chemistry and Laboratory Medicine » , vol. 63 , n. 5 , 2025 , pp. 1031-1042

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