Pubblicazioni

Autori:

Adamina, Michel; Ademuyiwa, Adesoji; Adisa, Adewale; Bhangu, Aneel A; Bravo, Ana Minaya; Cunha, Miguel F; Emile, Sameh; Ghosh, Dhruva; Glasbey, James C; Harris, Benjamin; Keller, Debby; Lawday, Samuel; Lederhuber, Hans; Leventoglu, Sezai; Li, Elizabeth; Modolo, Maria Marta; Mittal, Rohin; Mohan, Helen M; Nepogodiev, Dmitri; Parreño‐sacdalan, Marie Dione; Pata, Francesco; Pockney, Peter; Rutegård, Martin; Smart, Neil; Varghese, Chris; Glasbey, James C; Harris, Benjamin; Bhangu, Aneel A; Nepogodiev, Dmitri; Siaw‐acheampong, Kwabena; Benson, Ruth A; Bywater, Edward; Chaudhry, Daoud; Dawson, Brett E; Evans, Jonathan P; Glasbey, James C; Gujjuri, Rohan R; Heritage, Emily; Jones, Conor S; Kamarajah, Sivesh K; Khatri, Chetan; Khaw, Rachel A; Keatley, James M; Knight, Andrew; Lawday, Samuel; Li, Elizabeth; Mann, Harvinder S; Marson, Ella J; Mclean, Kenneth A; Mckay, Siobhan C; Mills, Emily C; Pellino, Gianluca; Picciochi, Maria; Taylor, Elliott H; Tiwari, Abhinav; Trout, Isobel M; Venn, Mary L; JW Wilkin, Richard; Bhangu, Aneel; Glasbey, James C; Smart, Neil J; Minaya‐bravo, Ana; Evans, Jonathan P; Gallo, Gaetano; Moug, Susan; Pata, Francesco; Pockney, Peter; Saverio, Salomone Di; Vallance, Abigail; Vimalchandran, Dale; Griffiths, Ewen A; Kamarajah, Sivesh K; Evans, Richard PT; Townend, Philip; Roberts, Keith; Mckay, Siobhan; Isaac, John; Satoi, Sohei; Edwards, John; Coonar, Aman S; Marchbank, Adrian; Caruana, Edward J; Layton, Georgia R; Patel, Akshay; Brunelli, Alessandro; Ford, Samuel; Desai, Anant; Gronchi, Alessandro; Fiore, Marco; Almond, Max; Tirotta, Fabio; Dumitra, Sinziana; Kolias, Angelos; Price, Stephen J; Fountain, Daniel M; Jenkinson, Michael D; Hutchinson, Peter; Marcus, Hani J; Piper, Rory J; Lippa, Laura; Servadei, Franco; Esene, Ignatius; Freyschlag, Christian; Neville, Iuri; Rosseau, Gail; Schaller, Karl; Demetriades, Andreas K; Robertson, Faith; Alamri, Alex; Shaw, Richard; Schache, Andrew G; Winter, Stuart C; Ho, Michael; Nankivell, Paul; Biel, Juan Rey; Batstone, Martin; Ganly, Ian; Vidya, Raghavan; Wilkins, Alex; Singh, Jagdeep K; Thekinkattil, Dinesh; Sundar, Sudha; Fotopoulou, Christina; Leung, Elaine YL; Khan, Tabassum; Chiva, Luis; Sehouli, Jalid; Fagotti, Anna; Cohen, Paul; Gutelkin, Murat; Ghebre, Rahel; Konney, Thomas; Pareja, Rene; Bristow, Rob; Dowdy, Sean; Shylasree, Ts; Seenivasagam, Rajkumar Kottayasamy; Ng, Joe; Fujiwara, Keiichi; Stewart, Grant D; Lamb, Benjamin; Narahari, Krishna; Mcneill, Alan; Colquhoun, Alexandra; Mcgrath, John S; Bromage, Steve; Barod, Ravi; Kasivisvanathan, Veeru; Klatte, Tobias; Abbott, Tom EF; Abukhalaf, Sadi; Adamina, Michel; Ademuyiwa, Adesoji O; Agarwal, Arnav; Akkulak, Murat; Alameer, Ehab; Alderson, Derek; Alakaloko, Felix; Albertsmeier, Markus; Alser, Osaid; Alshaar, Muhammad; Alshryda, Sattar; Arnaud, Alexis P; Augestad, Knut Magne; Ayasra, Faris; Azevedo, José; Bankhead‐kendall, Brittany K; Barlow, Emma; Beard, David; Benson, Ruth A; Blanco‐colino, Ruth; Brar, Amanpreet; Minaya‐bravo, Ana; Breen, Kerry A; Bretherton, Chris; Buarque, Igor Lima; Burke, Joshua; Caruana, Edward J; Chaar, Mohammad; Chakrabortee, Sohini; Christensen, Peter; Cox, Daniel; Cukier, Moises; Cunha, Miguel F; Davidson, Giana H; Desai, Anant; Saverio, Salomone Di; Drake, Thomas M; Edwards, John G; Elhadi, Muhammed; Emile, Sameh; Farik, Shebani; Fiore, Marco; Fitzgerald, J Edward; Ford, Samuel; Garmanova, Tatiana; Gallo, Gaetano; Ghosh, Dhruva; Gomes, Gustavo Mendonça Ataíde; Grecinos, Gustavo; Griffiths, Ewen A; Gruendl, Magdalena; Halkias, Constantine; Harrison, Ewen M; Hisham, Intisar; Hutchinson, Peter J; Hwang, Shelley; Isik, Arda; Jenkinson, Michael D; Jonker, Pascal; Kaafarani, Haytham MA; Keller, Debby; Kolias, Angelos; Kruijff, Schelto; Lawani, Ismail; Lederhuber, Hans; Leventoglu, Sezai; Litvin, Andrey; Loehrer, Andrew; Löffler, Markus W; Lorena, Maria Aguilera; Modolo, Maria Marta; Major, Piotr; Martin, Janet; Mashbari, Hassan N; Mazingi

Titolo:

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

COLORECTAL DISEASE

ISSN Rivista:

1462-8910

N° Volume:

24

Numero o Fascicolo:

6

Intervallo pagine:

708-726

Parole chiave:

COVID-19; SARS-CoV-2; colorectal cancer; coronavirus; surgery; surgical delay; COVID-19; SARS-CoV-2; colorectal cancer; coronavirus; surgery; surgical delay

Breve descrizione dei contenuti:

Aim The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. Methods This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. Results Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. Conclusion One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease.

Id prodotto:

133986

Handle IRIS:

11562/1083392

ultima modifica:

29 maggio 2023

Citazione bibliografica:

Adamina, Michel; Ademuyiwa, Adesoji; Adisa, Adewale; Bhangu, Aneel A; Bravo, Ana Minaya; Cunha, Miguel F; Emile, Sameh; Ghosh, Dhruva; Glasbey, James C; Harris, Benjamin; Keller, Debby; Lawday, Samuel; Lederhuber, Hans; Leventoglu, Sezai; Li, Elizabeth; Modolo, Maria Marta; Mittal, Rohin; Mohan, Helen M; Nepogodiev, Dmitri; Parreño‐sacdalan, Marie Dione; Pata, Francesco; Pockney, Peter; Rutegård, Martin; Smart, Neil; Varghese, Chris; Glasbey, James C; Harris, Benjamin; Bhangu, Aneel A; Nepogodiev, Dmitri; Siaw‐acheampong, Kwabena; Benson, Ruth A; Bywater, Edward; Chaudhry, Daoud; Dawson, Brett E; Evans, Jonathan P; Glasbey, James C; Gujjuri, Rohan R; Heritage, Emily; Jones, Conor S; Kamarajah, Sivesh K; Khatri, Chetan; Khaw, Rachel A; Keatley, James M; Knight, Andrew; Lawday, Samuel; Li, Elizabeth; Mann, Harvinder S; Marson, Ella J; Mclean, Kenneth A; Mckay, Siobhan C; Mills, Emily C; Pellino, Gianluca; Picciochi, Maria; Taylor, Elliott H; Tiwari, Abhinav; Trout, Isobel M; Venn, Mary L; JW Wilkin, Richard; Bhangu, Aneel; Glasbey, James C; Smart, Neil J; Minaya‐bravo, Ana; Evans, Jonathan P; Gallo, Gaetano; Moug, Susan; Pata, Francesco; Pockney, Peter; Saverio, Salomone Di; Vallance, Abigail; Vimalchandran, Dale; Griffiths, Ewen A; Kamarajah, Sivesh K; Evans, Richard PT; Townend, Philip; Roberts, Keith; Mckay, Siobhan; Isaac, John; Satoi, Sohei; Edwards, John; Coonar, Aman S; Marchbank, Adrian; Caruana, Edward J; Layton, Georgia R; Patel, Akshay; Brunelli, Alessandro; Ford, Samuel; Desai, Anant; Gronchi, Alessandro; Fiore, Marco; Almond, Max; Tirotta, Fabio; Dumitra, Sinziana; Kolias, Angelos; Price, Stephen J; Fountain, Daniel M; Jenkinson, Michael D; Hutchinson, Peter; Marcus, Hani J; Piper, Rory J; Lippa, Laura; Servadei, Franco; Esene, Ignatius; Freyschlag, Christian; Neville, Iuri; Rosseau, Gail; Schaller, Karl; Demetriades, Andreas K; Robertson, Faith; Alamri, Alex; Shaw, Richard; Schache, Andrew G; Winter, Stuart C; Ho, Michael; Nankivell, Paul; Biel, Juan Rey; Batstone, Martin; Ganly, Ian; Vidya, Raghavan; Wilkins, Alex; Singh, Jagdeep K; Thekinkattil, Dinesh; Sundar, Sudha; Fotopoulou, Christina; Leung, Elaine YL; Khan, Tabassum; Chiva, Luis; Sehouli, Jalid; Fagotti, Anna; Cohen, Paul; Gutelkin, Murat; Ghebre, Rahel; Konney, Thomas; Pareja, Rene; Bristow, Rob; Dowdy, Sean; Shylasree, Ts; Seenivasagam, Rajkumar Kottayasamy; Ng, Joe; Fujiwara, Keiichi; Stewart, Grant D; Lamb, Benjamin; Narahari, Krishna; Mcneill, Alan; Colquhoun, Alexandra; Mcgrath, John S; Bromage, Steve; Barod, Ravi; Kasivisvanathan, Veeru; Klatte, Tobias; Abbott, Tom EF; Abukhalaf, Sadi; Adamina, Michel; Ademuyiwa, Adesoji O; Agarwal, Arnav; Akkulak, Murat; Alameer, Ehab; Alderson, Derek; Alakaloko, Felix; Albertsmeier, Markus; Alser, Osaid; Alshaar, Muhammad; Alshryda, Sattar; Arnaud, Alexis P; Augestad, Knut Magne; Ayasra, Faris; Azevedo, José; Bankhead‐kendall, Brittany K; Barlow, Emma; Beard, David; Benson, Ruth A; Blanco‐colino, Ruth; Brar, Amanpreet; Minaya‐bravo, Ana; Breen, Kerry A; Bretherton, Chris; Buarque, Igor Lima; Burke, Joshua; Caruana, Edward J; Chaar, Mohammad; Chakrabortee, Sohini; Christensen, Peter; Cox, Daniel; Cukier, Moises; Cunha, Miguel F; Davidson, Giana H; Desai, Anant; Saverio, Salomone Di; Drake, Thomas M; Edwards, John G; Elhadi, Muhammed; Emile, Sameh; Farik, Shebani; Fiore, Marco; Fitzgerald, J Edward; Ford, Samuel; Garmanova, Tatiana; Gallo, Gaetano; Ghosh, Dhruva; Gomes, Gustavo Mendonça Ataíde; Grecinos, Gustavo; Griffiths, Ewen A; Gruendl, Magdalena; Halkias, Constantine; Harrison, Ewen M; Hisham, Intisar; Hutchinson, Peter J; Hwang, Shelley; Isik, Arda; Jenkinson, Michael D; Jonker, Pascal; Kaafarani, Haytham MA; Keller, Debby; Kolias, Angelos; Kruijff, Schelto; Lawani, Ismail; Lederhuber, Hans; Leventoglu, Sezai; Litvin, Andrey; Loehrer, Andrew; Löffler, Markus W; Lorena, Maria Aguilera; Modolo, Maria Marta; Major, Piotr; Martin, Janet; Mashbari, Hassan N; Mazingi, The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study «COLORECTAL DISEASE» , vol. 24 , n. 6 , 2022 , pp. 708-726

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo