Pubblicazioni

Autori:

Collatuzzo, Giulia; Visci, Giovanni; Violante, Francesco S; Porru, Stefano; Spiteri, Gianluca; Monaco, Maria Grazia Lourdes; Larese Fillon, Francesca; Negro, Corrado; Janke, Christian; Castelletti, Noemi; De Palma, Giuseppe; Sansone, Emanuele; Mates, Dana; Teodorescu, Silvia; Fabiánová, Eleonóra; Bérešová, Jana; Vimercati, Luigi; Tafuri, Silvio; Abedini, Mahsa; Ditano, Giorgia; Asafo, Shuffield S; Boffetta, Paolo; Zunarelli, Carlotta; Bonfiglioli, Roberta; Carta, Angela; Verlato, Giuseppe; Lippi, Giuseppe; Gibellini, Davide; Pezzani, Maria Diletta; Torroni, Lorena; Hoelscher, Michael; Wieser, Andreas; Reinkemeyer, Christina; Plank, Michael; Noreña, Ivan; Rubio-Acero, Raquel; Winter, Simon; Leustean, Mihaela; Perseca, Ovidiu; Ipate, Madalina; Agripina, Rascu; Strhársky, Jozef; Hellebrandt, Petra; Križanová, Daniela; Mrázová, Marianna; De Maria, Luigi; Sponselli, Stefania; Stefanizzi, Pasquale; Caputi, Antonio

Titolo:

Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers - ORCHESTRA project

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

FRONTIERS IN IMMUNOLOGY

ISSN Rivista:

1664-3224

N° Volume:

13

Intervallo pagine:

1-11

Parole chiave:

COVID – 19; health care workers (HCW); immune response; serology; vaccine; Antibodies, Viral; Female; Health Personnel; Humans; Immunity; Immunoglobulin G; Infant; Vaccination; COVID-19; COVID-19 Vaccines

Breve descrizione dei contenuti:

BackgroundThe duration of immune response to COVID-19 vaccination is of major interest. Our aim was to analyze the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose vaccination in an international cohort of vaccinated healthcare workers (HCWs). MethodsWe analyzed data on levels of anti-SARS-CoV-2 Spike antibodies and sociodemographic and clinical characteristics of 6,327 vaccinated HCWs from 8 centers from Germany, Italy, Romania and Slovakia. Time between 1(st) dose and serology ranged 150-210 days. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors, obtaining standardized values. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses. ResultsA 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (p<0.001) and heterologous vaccination (RR 2.46, 95%CI 1.87-3.24, one cohort) were associated with increased antibody levels. ConclusionsFemale gender, young age, past infection, two vaccine doses, and m-RNA and heterologous vaccination predicted higher antibody level at 6 months. These results corroborate previous findings and offer valuable data for comparison with trends observed with longer follow-ups.

Id prodotto:

130376

Handle IRIS:

11562/1079267

ultima modifica:

1 febbraio 2025

Citazione bibliografica:

Collatuzzo, Giulia; Visci, Giovanni; Violante, Francesco S; Porru, Stefano; Spiteri, Gianluca; Monaco, Maria Grazia Lourdes; Larese Fillon, Francesca; Negro, Corrado; Janke, Christian; Castelletti, Noemi; De Palma, Giuseppe; Sansone, Emanuele; Mates, Dana; Teodorescu, Silvia; Fabiánová, Eleonóra; Bérešová, Jana; Vimercati, Luigi; Tafuri, Silvio; Abedini, Mahsa; Ditano, Giorgia; Asafo, Shuffield S; Boffetta, Paolo; Zunarelli, Carlotta; Bonfiglioli, Roberta; Carta, Angela; Verlato, Giuseppe; Lippi, Giuseppe; Gibellini, Davide; Pezzani, Maria Diletta; Torroni, Lorena; Hoelscher, Michael; Wieser, Andreas; Reinkemeyer, Christina; Plank, Michael; Noreña, Ivan; Rubio-Acero, Raquel; Winter, Simon; Leustean, Mihaela; Perseca, Ovidiu; Ipate, Madalina; Agripina, Rascu; Strhársky, Jozef; Hellebrandt, Petra; Križanová, Daniela; Mrázová, Marianna; De Maria, Luigi; Sponselli, Stefania; Stefanizzi, Pasquale; Caputi, Antonio, Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers - ORCHESTRA project «FRONTIERS IN IMMUNOLOGY» , vol. 13 , 2022 , pp. 1-11

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