Pubblicazioni

Autori:

Benevolo, Giulia; Elli, Elena M.; Bartoletti, Daniela; Latagliata, Roberto; Tiribelli, Mario; Heidel, Florian H.; Cavazzini, Francesco; Bonifacio, Massimiliano; Crugnola, Monica; Binotto, Gianni; D( extquotesingle)Addio, Alessandra; Tieghi, Alessia; Bergamaschi, Micaela; Caocci, Giovanni; Polverelli, Nicola; Bossi, Elisa; Auteri, Giuseppe; Carmosino, Ida; Catani, Lucia; Cuneo, Antonio; Krampera, Mauro; Lanza, Francesco; Lemoli, Roberto M.; Vianelli, Nicola; Breccia, Massimo; Palumbo, Giuseppe A.; Cavo, Michele; Palandri, Francesca

Titolo:

Impact of comorbidities and body mass index on the outcome of polycythemia vera patients

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Hematological Oncology

ISSN Rivista:

0278-0232

N° Volume:

39

Numero o Fascicolo:

3

Intervallo pagine:

409-418

Parole chiave:

Charlson comorbidity index; body mass index; cancer; outcome; polycythemia vera; thrombotic risk; Adult; Aged; Aged, 80 and over; Comorbidity; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Polycythemia Vera; Primary Myelofibrosis; Retrospective Studies; Risk Factors; Thrombosis; Body Mass Index

Breve descrizione dei contenuti:

In 816 patients with 2016 World Health Organization-defined polycythemia vera (PV) enrolled in a multicenter retrospective study, we investigated the predictive value of Charlson comorbidity index (CCI) and body mass index (BMI) on thrombosis, progression to post-PV myelofibrosis (PPV-MF) and survival. Patients were subgrouped according to CCI = 0 (58.1%, no comorbidities) or CCI >= 1 (41.9%) and according to normal/underweight (BMI < 25, 54.5%) or overweight/obesity (BMI >= 25, 45.5%) at PV diagnosis. BMI was available for 529 patients. Patients with CCI >= 1 were older and more frequently presented cardiovascular risk factors compared to patients with CCI = 0 (p < 0.001), while overweight/obese patients were more frequently males (p < 0.001). Cumulative incidence of thromboses with death as competing risk was 13.3% at 10 years. Multivariable analysis with death as competing risk showed that previous thromboses (subdistribution hazard ratio [SHR]: 2.1, p = 0.01) and hypertension (SHR: 1.77, p = 0.04) were significantly associated with a higher thrombotic risk, while BMI >= 25 lost statistical significance (SHR: 1.69, p = 0.05) and CCI >= 1 was excluded after evaluation of goodness of fit. After a median follow-up of 6.1 years, progression to PPV-MF occurred in 44 patients, and 75 patients died. BMI >= 25 was associated with a lower probability of progression to PPV-MF (SHR: 0.38, CI95%: 0.15-0.94, p = 0.04) and better survival (hazard ratio [HR]: 0.42, CI95%: 0.18-0.97, p = 0.04). CCI >= 1 did not affect progression to PPV-MF (p = 0.44) or survival (p = 0.71). The evaluation of CCI and BMI may improve the prognostic definition of PV. In patients with hypertension an accurate evaluation of thrombotic risk is warranted.

Id prodotto:

122588

Handle IRIS:

11562/1049483

ultima modifica:

14 novembre 2024

Citazione bibliografica:

Benevolo, Giulia; Elli, Elena M.; Bartoletti, Daniela; Latagliata, Roberto; Tiribelli, Mario; Heidel, Florian H.; Cavazzini, Francesco; Bonifacio, Massimiliano; Crugnola, Monica; Binotto, Gianni; D( extquotesingle)Addio, Alessandra; Tieghi, Alessia; Bergamaschi, Micaela; Caocci, Giovanni; Polverelli, Nicola; Bossi, Elisa; Auteri, Giuseppe; Carmosino, Ida; Catani, Lucia; Cuneo, Antonio; Krampera, Mauro; Lanza, Francesco; Lemoli, Roberto M.; Vianelli, Nicola; Breccia, Massimo; Palumbo, Giuseppe A.; Cavo, Michele; Palandri, Francesca, Impact of comorbidities and body mass index on the outcome of polycythemia vera patients «Hematological Oncology» , vol. 39 , n. 3 , 2021 , pp. 409-418

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