Pubblicazioni

Autori:

Riolfi M; Ferla R; Valle LD; Piña-Oviedo S; Scolaro L; Micciolo R; Guidi M; Terrasi M; Cetto GL; Surmacz E

Titolo:

Leptin and Its Receptor are Overexpressed in Brain Tumors and Correlate with the Degree of Malignancy

Anno:

2009

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

No

Nome rivista:

Brain Pathology

ISSN Rivista:

1015-6305

N° Volume:

20

Numero o Fascicolo:

2

Intervallo pagine:

481-489

Codice PMID:

19775291

Parole chiave:

glioblastoma, leptin, leptin receptor, malignant progression, novel biomarker

Breve descrizione dei contenuti:

Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown. We screened 87 human brain tumor biopsies using immunohistochemistry and detected leptin and ObR in 55.2% and 60.9% cases, respectively. In contrast, leptin and ObR were absent in 14 samples of normal brain tissue. The presence of leptin correlated with ObR with overall concordance 80.5%. The leptin/ObR system was highly expressed in glioblastomas and anaplastic astrocytomas, while lower expression of both markers was noted in low-grade astrocytomas and gangliogliomas. The association between leptin/ObR and the degree of tumor malignancy was highly significant (P < 0.001). Using double immunofluorescence of glioblastoma tissues, we found co-expression of leptin with ObR and with the proliferation marker Ki-67 in 87% and 64% of cells, respectively. The leptin/ObR-positive tissues also expressed activated forms of STAT3 and Akt. In line with this finding, ObR-positive glioblastoma cells responded to leptin with cell growth and induction of the STAT3 and Akt pathways as well as inactivation of the cell cycle suppressor Rb. In summary, our data demonstrate that the leptin/ObR system is expressed in malignant brain tumors and might be involved in tumor progression.

Id prodotto:

55935

Handle IRIS:

11562/340273

depositato il:

11 maggio 2012

ultima modifica:

2 novembre 2016

Citazione bibliografica:

Riolfi M; Ferla R; Valle LD; Piña-Oviedo S; Scolaro L; Micciolo R; Guidi M; Terrasi M; Cetto GL; Surmacz E, Leptin and Its Receptor are Overexpressed in Brain Tumors and Correlate with the Degree of Malignancy «Brain Pathology» , vol. 20 , n. 2 , 2009 , pp. 481-489

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