- Autori:
-
Brunello, A.; Saia, G.; Bedogni, Alberto; Scaglione, D.; Basso, U.
- Titolo:
-
Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma
- Anno:
-
2009
- Tipologia prodotto:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Lingua:
-
Inglese
- Referee:
-
Sì
- Nome rivista:
- Bone
- ISSN Rivista:
- 8756-3282
- Intervallo pagine:
-
173-175
- Parole chiave:
-
osteonecrosis; jaw; sunitinib; cancer
- Breve descrizione dei contenuti:
- We report on the potential association of suspected bisphosphonate-associated osteonecrosis of the jaw
(BRONJ) recurrence with the use of the novel antiangiogenic drug sunitinib. A 59 year-old patient affected by
metastatic renal cell carcinoma (RCC) and established BRONJ experienced consecutive episodes of painful jaw
infection with cutaneous fistula and bone sequestration which occurred during active treatment with
sunitinib, improved after discontinuation and antibiotic therapy, then rapidly worsened with resumption of
sunitinib. We hypothesize that the potent antiangiogenic activity of sunitinib may amplify the inhibition of
bone remodeling exerted by aminobisphosphonates entrapped within the osteonecrotic mineral matrix,
antagonize mucosal healing and expose to infections during treatment. This supports the emerging role of
soft-tissue damage in the pathogenesis of osteonecrosis of the jaw.
- Id prodotto:
-
51455
- Handle IRIS:
-
11562/334274
- depositato il:
-
29 marzo 2012
- ultima modifica:
-
14 novembre 2022
- Citazione bibliografica:
-
Brunello, A.; Saia, G.; Bedogni, Alberto; Scaglione, D.; Basso, U.,
Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma
«Bone»
,
2009
,
pp. 173-175
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