Pubblicazioni

Autori:

Young, Ken; Shi, Wen-Yu; Xu-Monette, Zijun; Jia, Youchao; Tzankov, Alexandar; Go, Heounjeong; Li, Ling; Ponzoni, Maurilio; Wang, Yafei; Zhai, Qiongli; Perry, Anamarija; Wang, Shi; Wang, Xiaoxiao; Chiu, April; Xu, Mina; Visco, Carlo; Dybkaer, Karen; Withers, Henry; Long, Mark; Yuan, Alyssa; Miao, Yi; Li, Jianyong; Macias, Everardo; Shuai, Wen; Wang, Bangchen; Bhagat, Govind; Zu, Youli; Pan, Zenggang; Choi, William; Montes-Moreno, Santiago; Chen, Weina; Van Krieken, J Han; Møller, Michael; Zhan, Fenghuang; Parsons, Ben; Zhang, Shanxiang; Hsi, Eric; Sohani, Aliyah; Abramson, Jeremy; Ferreri, Andrés; Xu, Bing; Li, Yong

Titolo:

Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

BLOOD CANCER JOURNAL

ISSN Rivista:

2044-5385

Intervallo pagine:

123-135

Parole chiave:

Lymphoma

Breve descrizione dei contenuti:

Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive lymphoma with molecular heterogeneity not well characterize. In this study, we performed next-generation sequencing analysis for a large number of DNA and RNA samples from patients with PT-DLBCL. DNA sequencing analysis identified ≥ 3 chromosomes with copy number variations (CNVs) and microsatellite instability as prognostic biomarkers, rather than MYD88 mutations and genetic subtypes. Remarkably, targeted RNA-seq analysis in 195 patients revealed that TP53 mutations with a ≥ 40% variant allele frequency had significantly adverse prognostic impact, and that a 150-gene expression signature subdivided PT-DLBCL into two distinct clusters, termed as testicular lymphoma tumor (TLT) and microenvironment (ME) subtypes. The TLT subtype featured upregulation of genes involved in B-cell receptor signaling, cell cycle, DNA damage and repair, higher frequencies of CNVs and MYD88 mutations, elder ages, larger tumor sizes, and significantly poorer survival. Genomic microRNA profiling analysis identified significantly differentially expressed microRNAs between 113 PT-DLBCL and 180 systemic DLBCL patients, and further subdivided the PT-DLBCL cohort by microRNA signatures. The subcohort with upregulation of 16 microRNAs associated with PT-DLBCL and testicular tissue expression had significantly better survival. This study revealed characteristic genetic, gene expression, and microRNA profiles and heterogeneity in PT-DLBCL.

Id prodotto:

146939

Handle IRIS:

11562/1168647

ultima modifica:

21 agosto 2025

Citazione bibliografica:

Young, Ken; Shi, Wen-Yu; Xu-Monette, Zijun; Jia, Youchao; Tzankov, Alexandar; Go, Heounjeong; Li, Ling; Ponzoni, Maurilio; Wang, Yafei; Zhai, Qiongli; Perry, Anamarija; Wang, Shi; Wang, Xiaoxiao; Chiu, April; Xu, Mina; Visco, Carlo; Dybkaer, Karen; Withers, Henry; Long, Mark; Yuan, Alyssa; Miao, Yi; Li, Jianyong; Macias, Everardo; Shuai, Wen; Wang, Bangchen; Bhagat, Govind; Zu, Youli; Pan, Zenggang; Choi, William; Montes-Moreno, Santiago; Chen, Weina; Van Krieken, J Han; Møller, Michael; Zhan, Fenghuang; Parsons, Ben; Zhang, Shanxiang; Hsi, Eric; Sohani, Aliyah; Abramson, Jeremy; Ferreri, Andrés; Xu, Bing; Li, Yong, Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma «BLOOD CANCER JOURNAL» , 2025 , pp. 123-135

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