Pubblicazioni

Autori:

Averbuch, D; Tridello, G; Hoek, J; Mikulska, M; Pabst, T; Segundo, Lys; Akan, H; Özçelik, T; Donnini, I; Klyasova, G; de Sousa, Ab; Zuckerman, T; Tecchio, C; Camara, R; Aki, Sz; Ljungman, P; Gülbas, Z; Nicolas-Virelizier, E; Calore, E; Perruccio, K; Ram, R; Annaloro, C; Martino, R; Avni, B; Shaw, Pj; Jungova, A; Codeluppi, K; O'Brien, T; Waszczuk-Gajda, A; Batlle, M; Pouli, A; Lueck, C; Gil, L; Iacobelli, S; Styczynski, J; Engelhard, D; Cesaro, S.

Titolo:

Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality.

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Infection

ISSN Rivista:

0163-4453

Intervallo pagine:

882-894

Parole chiave:

Bacteremia; Fluoroquinolone prophylaxis; Gram-negative; Mortality; Post-engraftment; Pre-engraftment; Risk factors; Stem cell transplantation

Breve descrizione dei contenuti:

Objectives: We present here data on Gram-negative rods bacteremia (GNRB) rates, risk factors and associated mortality. Methods: Data on GNRB episodes were prospectively collected in 65 allo-/67 auto-HSCT centers in 24 countries (Europe, Asia, Australia). In patients with and without GNRB, we compared: demography, underlying disease, HSCT-related data, center` fluoroquinolone prophylaxis (FQP) policy and accreditation status, and involvement of infection control team (ICT). Results: The GNRB cumulative incidence among 2818 allo-HSCT was: pre-engraftment (pre-eng-allo-HSCT), 8.4 (95% CI 7-9%), post-engraftment (post-eng-allo-HSCT), 5.8% (95%CI: 5-7%); among 3152 auto-HSCT, pre-eng-auto-HSCT, 6.6% (95%CI: 6-7%), post-eng-auto-HSCT, 0.7% (95%CI: 0.4-1.1%). GNRB, especially MDR, was associated with increased mortality. Multivariate analysis revealed the following GNRB risk factors: (a) pre-eng-allo-HSCT: south-eastern Europe center location, underlying diseases not at complete remission, and cord blood source; (b) post-eng-allo-HSCT: center location not in northwestern Europe; underlying non-malignant disease, not providing FQP and never accredited. (c) pre-eng-auto-HSCT: older age, autoimmune and malignant (vs. plasma cell) disease, and ICT absence. Conclusions: Benefit of FQP should be explored in prospective studies. Increased GNRB risk in auto-HSCT patients transplanted for autoimmune diseases is worrying. Infection control and being accredited are possibly protective against bacteremia. GNRB are associated with increased mortality.

Id prodotto:

145979

Handle IRIS:

11562/1162972

ultima modifica:

25 maggio 2025

Citazione bibliografica:

Averbuch, D; Tridello, G; Hoek, J; Mikulska, M; Pabst, T; Segundo, Lys; Akan, H; Özçelik, T; Donnini, I; Klyasova, G; de Sousa, Ab; Zuckerman, T; Tecchio, C; Camara, R; Aki, Sz; Ljungman, P; Gülbas, Z; Nicolas-Virelizier, E; Calore, E; Perruccio, K; Ram, R; Annaloro, C; Martino, R; Avni, B; Shaw, Pj; Jungova, A; Codeluppi, K; O'Brien, T; Waszczuk-Gajda, A; Batlle, M; Pouli, A; Lueck, C; Gil, L; Iacobelli, S; Styczynski, J; Engelhard, D; Cesaro, S., Intercontinental study on pre-engraftment and post-engraftment Gram-negative rods bacteremia in hematopoietic stem cell transplantation patients: Risk factors and association with mortality. «Journal of Infection» , 2020 , pp. 882-894

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