Pubblicazioni

Autori:

Serafin, Andrea; Cellini, Alessandro; Martino, Enrica Antonia; Mazzetto, Federica; Angotzi, Francesco; Frustaci, Anna Maria; Marchetti, Monia; Moia, Riccardo; Sanna, Alessandro; Riemma, Costantino; Cibien, Francesca; Noto, Alessandro; Lista, Enrico; Foglietta, Myriam; Vitale, Candida; Innao, Vanessa; Bullo, Martina; Lovato, Ester; Ferrarini, Isacco; Andriola, Costanza; Ballotta, Laura; Innocenti, Idanna; Fresa, Alberto; Favrin, Gianmarco; Varettoni, Marzia; Santambrogio, Elisa; Orsucci, Lorella; Pasquale, Raffaella; Moratti, Massimo; Laurenti, Luca; Coscia, Marta; Sportoletti, Paolo; Marasca, Roberto; Mauro, Francesca Romana; Patti, Caterina; Derenzini, Enrico; Scarfò, Lydia; Ghia, Paolo; Cuneo, Antonio; Tedeschi, Alessandra; Trentin, Livio; Gentile, Massimo; Visentin, Andrea

Titolo:

Venetoclax based regimens in octogenarian CLL patients: efficacy, safety and comparison to BTKi in a multicenter cohort

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

BLOOD ADVANCES

ISSN Rivista:

2473-9529

Intervallo pagine:

1-12

Parole chiave:

chronic lymphocytic leukemia

Breve descrizione dei contenuti:

Octogenarians represent a significant fraction of patients with Chronic Lymphocytic Leukemia (CLL) but, despite the prevalence of the disease in this age group, limited data is available on the safety and efficacy of novel drugs in this subgroup. We conducted a multicenter, retrospective study enrolling 120 octogenarian patients who received Venetoclax (Ven) regimens in any line. Regarding efficacy, we found Ven to perform similarly to what is reported in younger patients with CLL, with an overall response rate of 91%, a complete response rate of 44% and median progression-free survival of 44 months. Concerning safety, we report a toxicity profile that is consistent with previous reports, with most high-grade adverse events being of hematological or infectious nature, as 37% and 22% of patients experienced neutropenia or infections of grade 3 or higher. As part of our study, we compared the safety and efficacy data we collected with those obtained in a comparable BTKi-treated population. We found that these two treatments were comparable in terms of overall efficacy, barring a higher rate of complete responses with Ven; safety profiles were different among the two groups as BTKi-treated patients had more cardiovascular toxicities (26% vs 4%) and Ven-treated subjects experienced more infectious events (82% vs 49%). Our data points out that Ven-based regimens are safe and effective in octogenarian patients with CLL despite their higher clinical complexity and comorbidity burden and should provide some basis for the design of prospective studies to further evaluate the optimal treatment regimen in this patient population.

Id prodotto:

145805

Handle IRIS:

11562/1162254

ultima modifica:

16 maggio 2025

Citazione bibliografica:

Serafin, Andrea; Cellini, Alessandro; Martino, Enrica Antonia; Mazzetto, Federica; Angotzi, Francesco; Frustaci, Anna Maria; Marchetti, Monia; Moia, Riccardo; Sanna, Alessandro; Riemma, Costantino; Cibien, Francesca; Noto, Alessandro; Lista, Enrico; Foglietta, Myriam; Vitale, Candida; Innao, Vanessa; Bullo, Martina; Lovato, Ester; Ferrarini, Isacco; Andriola, Costanza; Ballotta, Laura; Innocenti, Idanna; Fresa, Alberto; Favrin, Gianmarco; Varettoni, Marzia; Santambrogio, Elisa; Orsucci, Lorella; Pasquale, Raffaella; Moratti, Massimo; Laurenti, Luca; Coscia, Marta; Sportoletti, Paolo; Marasca, Roberto; Mauro, Francesca Romana; Patti, Caterina; Derenzini, Enrico; Scarfò, Lydia; Ghia, Paolo; Cuneo, Antonio; Tedeschi, Alessandra; Trentin, Livio; Gentile, Massimo; Visentin, Andrea, Venetoclax based regimens in octogenarian CLL patients: efficacy, safety and comparison to BTKi in a multicenter cohort «BLOOD ADVANCES» , 2025 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo