Pubblicazioni

Autori:

Pegoraro, Veronica; Viellevoye, Renaud; Malfilatre, Geneviève; Dilena, Robertino; Proietti, Jacopo; Mauro, Isabella; Zardini, Cecilia; Dzietko, Mark; Lacan, Laure; Desnous, Beatrice; Cordelli, Duccio Maria; Campi, Francesca; Da Silva, Monica Reis; Fumagalli, Monica; Nguyen The Tich, Sylvie; Felderhoff-Müser, Ursula; Ventura, Giulia; Sartori, Stefano; Benders, Manon; Pittini, Carla; Cavicchiolo, Maria Elena; Milh, Mathieu; Cantalupo, Gaetano; van Maanen, Aline; Tataranno, Maria Luisa; Cilio, Maria Roberta

Titolo:

Effectiveness of sodium channel blockers in treating neonatal seizures due to arterial ischemic stroke

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Epilepsia

ISSN Rivista:

0013-9580

N° Volume:

66

Numero o Fascicolo:

2

Intervallo pagine:

394-406

Parole chiave:

EEG; aEEG; antiseizure medications; neonatal acute ischemic stroke; neonatal seizures

Breve descrizione dei contenuti:

Objective: Few studies have evaluated the efficacy of antiseizure medications (ASMs) according to the etiology of neonatal acute provoked seizures. We aimed to investigate the response to ASMs in term/near term neonates with acute arterial ischemic stroke (AIS), as well as the type of seizure at presentation and the monitoring approach. Methods: We retrospectively evaluated neonates from 15 European level IV neonatal intensive care units who presented with seizures due to AIS and were monitored by continuous electroencephalography (cEEG) and/or amplitude-integrated EEG (aEEG) in whom actual recordings, timing, doses, and response to ASMs were available for review. Results: One hundred seven neonates were referred, and 88 were included. Of those, 56 met the criteria for evaluating the treatment response. The mean time to treatment was 7.9 h (SD = 16.4), and the most frequently administered first-line ASM was phenobarbital (PB; 74/88, 84.1%). Seizures were controlled within 24 h from onset of symptoms in 64.3% (36/56) of neonates. Phenytoin (PHT) was effective in almost all neonates in whom it was trialed (24/25, 96.0%), whereas PB was effective in only 22.0% of patients (11/50). Infants treated with PB or PHT as first-line treatment (53/56, 94.6%) showed a higher response rate with PHT (6/6, 100.0%) than with PB (11/47, 23.4%). Monitoring approach and seizure types were evaluated in 88 infants. Forty-six of 88 (52.3%) were monitored with cEEG and 47.7% (42/88) with aEEG, with or without intermittent cEEG. The mean monitoring duration was 65.8 h (SD = 39.21). In 83 of 88 (94.3%) infants, the type of seizure suspected clinically prior to monitoring was confirmed afterward. Unilateral focal clonic seizures were seen in 71 of 88 infants (80.7%), whereas 11 of 88 (12.5%) presented with ictal apneas. Significance: Our findings provide evidence in a large, homogenous cohort that PHT is more effective than PB in treating neonatal acute symptomatic seizures due to AIS.

Id prodotto:

145630

Handle IRIS:

11562/1161510

ultima modifica:

9 maggio 2025

Citazione bibliografica:

Pegoraro, Veronica; Viellevoye, Renaud; Malfilatre, Geneviève; Dilena, Robertino; Proietti, Jacopo; Mauro, Isabella; Zardini, Cecilia; Dzietko, Mark; Lacan, Laure; Desnous, Beatrice; Cordelli, Duccio Maria; Campi, Francesca; Da Silva, Monica Reis; Fumagalli, Monica; Nguyen The Tich, Sylvie; Felderhoff-Müser, Ursula; Ventura, Giulia; Sartori, Stefano; Benders, Manon; Pittini, Carla; Cavicchiolo, Maria Elena; Milh, Mathieu; Cantalupo, Gaetano; van Maanen, Aline; Tataranno, Maria Luisa; Cilio, Maria Roberta, Effectiveness of sodium channel blockers in treating neonatal seizures due to arterial ischemic stroke «Epilepsia» , vol. 66 , n. 2 , 2024 , pp. 394-406

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