- Autori:
-
Conti, Anita
- Titolo:
-
The regenerative potential of stromal vascular fraction delivery via hyaluronic acid in an ischemia-reperfusion injury model
- Anno:
-
2024
- Tipologia prodotto:
-
Doctoral Thesis
- Lingua:
-
Inglese
- Parole chiave:
-
ischemia reperfusion injury, stromal vascular fraction, hyaluronic acid
- Abstract (italiano):
- Tissue engineering, in recent years, has shown interesting applications, particularly
in regenerative medicine with the aim of improving the renewal and repair of
damaged tissues. In this context, the use of stromal vascular fraction (SVF) from
adipose tissue, combined with biomaterials has demonstrated remarkable potential
in promoting tissue recovery. SVF, due to its multipotency and immunomodulatory
properties, provides interesting evidences of high therapeutic potential. In addition,
hyaluronic acid (HyA) has emerged as a versatile biomaterial renowned for its
biodegradable, biocompatible, and bioactive properties.
The aim of this study was to assess the regenerative potential of SVF with an HyA
in a model of muscular ischemia-reperfusion (I/R) injury. The first part of the study
focused on in vitro and in vivo characterization of SVF obtained through mechanical
fragmentation of adipose tissue and its with HyA. Subsequently, the regenerative
potential of SVF combined with HyA was assessed in a model of skeletal muscle
I/R injury. Multiparametric MRI evaluations, motor function tests, quantitative
analyses, and immunohistochemical examinations demonstrated that the SVF
combined with HyA treatment induced significant improvements in the
experimental model. In particular, we observed a reduction of edema, a positive
impact on motor function impairment, and myofibril organization compared to
individual SVF or HyA treatments. Overall, the results showed that the synergistic
effect of SVF and HyA could represent an efficient treatment for skeletal muscle
ischemia-reperfusion injury with high translational potential for future clinical
studies.
- Id prodotto:
-
140287
- Handle IRIS:
-
11562/1129706
- ultima modifica:
-
28 giugno 2024
- Citazione bibliografica:
-
Conti, Anita,
The regenerative potential of stromal vascular fraction delivery via hyaluronic acid in an ischemia-reperfusion injury model
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