Publications

Authors:

Riolfi M; Ferla R; Valle LD; Piña-Oviedo S; Scolaro L; Micciolo R; Guidi M; Terrasi M; Cetto GL; Surmacz E

Title:

Leptin and Its Receptor are Overexpressed in Brain Tumors and Correlate with the Degree of Malignancy

Year:

2009

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

No

Name of journal:

Brain Pathology

ISSN of journal:

1015-6305

N° Volume:

20

Number or Folder:

2

Page numbers:

481-489

Code PMID:

19775291

Keyword:

glioblastoma, leptin, leptin receptor, malignant progression, novel biomarker

Short description of contents:

Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown. We screened 87 human brain tumor biopsies using immunohistochemistry and detected leptin and ObR in 55.2% and 60.9% cases, respectively. In contrast, leptin and ObR were absent in 14 samples of normal brain tissue. The presence of leptin correlated with ObR with overall concordance 80.5%. The leptin/ObR system was highly expressed in glioblastomas and anaplastic astrocytomas, while lower expression of both markers was noted in low-grade astrocytomas and gangliogliomas. The association between leptin/ObR and the degree of tumor malignancy was highly significant (P < 0.001). Using double immunofluorescence of glioblastoma tissues, we found co-expression of leptin with ObR and with the proliferation marker Ki-67 in 87% and 64% of cells, respectively. The leptin/ObR-positive tissues also expressed activated forms of STAT3 and Akt. In line with this finding, ObR-positive glioblastoma cells responded to leptin with cell growth and induction of the STAT3 and Akt pathways as well as inactivation of the cell cycle suppressor Rb. In summary, our data demonstrate that the leptin/ObR system is expressed in malignant brain tumors and might be involved in tumor progression.

Product ID:

55935

Handle IRIS:

11562/340273

Deposited On:

May 11, 2012

Last Modified:

November 2, 2016

Bibliographic citation:

Riolfi M; Ferla R; Valle LD; Piña-Oviedo S; Scolaro L; Micciolo R; Guidi M; Terrasi M; Cetto GL; Surmacz E, Leptin and Its Receptor are Overexpressed in Brain Tumors and Correlate with the Degree of Malignancy «Brain Pathology» , vol. 20 , n. 2 , 2009 , pp. 481-489

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo