Publications

Authors:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Donatelli, Luca; Bertoldo, Francesco; Giovanazzi, Benedetta; Caliari, Francesco; LO CASCIO, Vincenzo

Title:

STEAP mRNA detection in serum of patients with solid tumours.

Year:

2009

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Cancer Letters

ISSN of journal:

0304-3835

N° Volume:

273

Number or Folder:

1

Page numbers:

122-126

Keyword:

STEAP; cancer; serum

Short description of contents:

STEAP was identified by the strategy of suppression subtractive hybridizations in Los Angeles prostate cancer xenografts. It is expressed in prostate and other cancers, and not in most normal tissue; it can be used as a marker to evaluate biological samples from individuals suspected of having a disease associated with STEAP dysregulation, such as cancers, and may provide prognostic information useful in defining appropriate therapeutic options. The aim of this study was to test the STEAP mRNA detection in the serum of patients with different malignant tumours by using Real-Time reverse transcription PCR. The results were compared with biological samples obtained by age-matched non-malignant donors. Our data demonstrated that STEAP mRNA is detectable in serum of patients with different solid tumours whereas it is not amplifiable in non-malignant donors. This marker revealed with the molecular method of quantitative PCR in serum, may be useful to discriminate normal and cancer patients.

Product ID:

55091

Handle IRIS:

11562/323868

Deposited On:

July 14, 2012

Last Modified:

November 29, 2022

Bibliographic citation:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Donatelli, Luca; Bertoldo, Francesco; Giovanazzi, Benedetta; Caliari, Francesco; LO CASCIO, Vincenzo, STEAP mRNA detection in serum of patients with solid tumours. «Cancer Letters» , vol. 273 , n. 1 , 2009 , pp. 122-126

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