Publications

Authors:

Franchini, M; Rossetti, G; Tagliaferri, A; Capra, Franco; de Maria, E; Pattacini, C; Lippi, Giuseppe; LO CASCIO, Giuliana; de Gironcoli, M; Gandini, G.

Title:

The natural history of chronic hepatitis C in a cohort of HIV negative Italian patients with hereditary bleeding disorders

Year:

2001

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Blood

ISSN of journal:

0006-4971

N° Volume:

98

Number or Folder:

6

:

American Society of Hematology

Page numbers:

1836-1841

Keyword:

chronic hepatitis C; HIV; bleeding disorder

Short description of contents:

This study looked at 102 anti-hepatitis C virus (HCV)-positive, hepatitis B virus (HBV)-negative, and HIV-negative patients (median age, 45.1 years; range, 15-71) affected by hereditary bleeding disorders who have been infected with HCV for 15 to 34 years (median, 25.1). All these patients were infected before the mid 1980s because of non-virally inactivated pooled blood products. Fourteen patients (13.7%) were HCV-RNA negative with no signs of liver disease and were considered to have cleared the virus. Eighty-eight patients (86.3%) were HCV-RNA positive. The HCV genotype distribution was 1 a in 20.5%, 1 b in 36.4%, 2 in 17.0%, 3 in 15.9%, 4 in 3.4%, and mixed in 6.8% of cases. Twenty-four patients (23.5%) had serum cryoglobulins, symptomatic in 4 cases, and associated with liver disease and with genotype 1. Among the 88 HCV-RNA-positive patients, 15 (17.0%) had normal alanine aminotransferase levels and abdominal ultrasound, 61 (69.3%) had nonprogressive chronic hepatitis, and 12 (13.7%) had severe liver disease (6 [6.9%] liver cirrhosis, 4 [4.5%] hepatic decompensation, and 2 [2.3%] hepatocellular carcinoma) after a follow-up period of 25 years. There were 3 (3.4%) liver-related deaths. HCV genotype 1, patient's age at evaluation, duration of infection, and severity of congenital bleeding disorder were associated with more advanced liver disease. The results confirm the slow progression of HCV infection in HIV-negative hemophiliacs.

Product ID:

12542

Handle IRIS:

11562/300872

Deposited On:

November 13, 2012

Last Modified:

March 17, 2024

Bibliographic citation:

Franchini, M; Rossetti, G; Tagliaferri, A; Capra, Franco; de Maria, E; Pattacini, C; Lippi, Giuseppe; LO CASCIO, Giuliana; de Gironcoli, M; Gandini, G., The natural history of chronic hepatitis C in a cohort of HIV negative Italian patients with hereditary bleeding disorders «Blood» , vol. 98 , n. 6 , 2001 , pp. 1836-1841

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