Publications

Authors:

Langtry, Alberto; Rabadan, Raul; Alonso, Lola; Filip, Ioan; Sabroso-Lasa, Sergio; Moreno-Oya, Ane; Lawlor, Rita; Carrato, Alfredo; Alvarez-Gallego, Rafael; Iglesias, Mar; Molero, Xavier; Löhr, Matthias J; Michalski, Christoph W; Perea, José; O'Rorke, Michael; Barberà, Victor M; Tardón, Adonina; Farré, Antoni; Muñoz-Bellvís, Luís; Crnogorac-Jurcevic, Tatjana; Domínguez-Muñoz, Enrique; Gress, Thomas M; Greenhalf, William; Sharp, Linda; Balsells, Joaquim; Costello, Eithne; Kleeff, Jörg; Kong, Bo; Mora, Josefina; O'Driscoll, Damian; Scarpa, Aldo; Ye, Weimin; Real, Francisco X; López De Maturana, Evangelina; Malats, Núria; Pangeneu Consortium, Investigators

Title:

Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

NATURE COMMUNICATIONS

ISSN of journal:

2041-1723

N° Volume:

16

Number or Folder:

1

Page numbers:

1-12

Keyword:

Carcinoma, Pancreatic Ductal; Complement System Proteins; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Pancreatic Neoplasms; Polymorphism, Single Nucleotide; Prognosis

Short description of contents:

: Pancreatic ductal adenocarcinoma (PDAC) genetic susceptibility is partially identified. The complement system (CS) influences carcinogenesis and participates in immunological defense and homeostasis; however, its role in PDAC genetic susceptibility and prognosis is underexplored. The association of SNPs within 111 CS-related genes with PDAC risk is assessed in the PanGenEU study and validated in the UKBiobank. We investigate the association between the CS-related gene variation and PDAC risk, followed by an in-depth functional in silico study using TCGA and ICGC data. We assess whether CS-related genes are associated with prognosis at the germline and somatic levels. We investigate the immune infiltration of PDAC tumors according to their transcriptomic profile. Genetic variation in FCN1 and PLAT is significantly associated with PDAC risk. PDAC patients with elevated expression of IGHG3, IGKC, IGHM, F2R, F2RL2, CFI, A2M, or C4A display improved survival and higher infiltration of CD8+, B cells, and Th1 cells. Individuals with high expression levels of either FGA, SERPINE1, FGG, or F3 exhibit poorer survival, higher infiltration of Tregs, and lower infiltration of CD8+ cells. Results from this study suggest that CS-related genes play a role in PDAC genetic susceptibility and survival through specific immune cell infiltration.

Product ID:

148653

Handle IRIS:

11562/1176407

Last Modified:

December 20, 2025

Bibliographic citation:

Langtry, Alberto; Rabadan, Raul; Alonso, Lola; Filip, Ioan; Sabroso-Lasa, Sergio; Moreno-Oya, Ane; Lawlor, Rita; Carrato, Alfredo; Alvarez-Gallego, Rafael; Iglesias, Mar; Molero, Xavier; Löhr, Matthias J; Michalski, Christoph W; Perea, José; O'Rorke, Michael; Barberà, Victor M; Tardón, Adonina; Farré, Antoni; Muñoz-Bellvís, Luís; Crnogorac-Jurcevic, Tatjana; Domínguez-Muñoz, Enrique; Gress, Thomas M; Greenhalf, William; Sharp, Linda; Balsells, Joaquim; Costello, Eithne; Kleeff, Jörg; Kong, Bo; Mora, Josefina; O'Driscoll, Damian; Scarpa, Aldo; Ye, Weimin; Real, Francisco X; López De Maturana, Evangelina; Malats, Núria; Pangeneu Consortium, Investigators, Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis «NATURE COMMUNICATIONS» , vol. 16 , n. 1 , 2025 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo