Publications

Authors:

Brusini, Lorenza; Dolci, Giorgio; Pini, Lorenzo; Cruciani, Federica; Pizzagalli, Fabrizio; Provero, Paolo; Menegaz, Gloria; BOSCOLO GALAZZO, Ilaria

Title:

Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer’s Disease Continuum

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN of journal:

1422-0067

N° Volume:

25

Number or Folder:

23

Page numbers:

1-16

Keyword:

T1-weighted MRI; Diffusion MRI; ADNI; Partial Least Squares; Gene expression; Enrich- 13 ment analysis

Short description of contents:

Bridging the gap between cortical morphometric remodeling and gene expression can help 1 to clarify the effects of the selective brain accumulation of Amyloid-β (Aβ) and tau proteins occurring 2 in the Alzheimer’s Disease (AD). To this aim, we derived morphometric similarity (MS) networks from 3 126 Aβ and tau positive (Aβ+/tau+) and 172 Aβ-/tau- subjects, and we investigated the association 4 between group-wise regional MS differences and transcriptional correlates thanks to an imaging 5 transcriptomics approach grounding on the Allen Human Brain Atlas (AHBA). The expressed gene 6 with the highest correlation with MS alterations was BCHE, a gene related to Aβ homeostasis. In 7 addition, notably, among the most promising results derived from the enrichment analysis, we found 8 the immune response as biological process, and astrocytes, microglia, and oligodendrocyte precursors 9 for the cell types. In summary, by relating cortical MS and AHBA-derived transcriptomics, we were 10 able to retrieve findings suggesting the biological mechanisms underlying the Aβ and tau-induced 11 cortical MS alterations in the AD continuum.

Web page:

https://www.mdpi.com/1422-0067/25/23/12871

Product ID:

142871

Handle IRIS:

11562/1146007

Last Modified:

February 19, 2025

Bibliographic citation:

Brusini, Lorenza; Dolci, Giorgio; Pini, Lorenzo; Cruciani, Federica; Pizzagalli, Fabrizio; Provero, Paolo; Menegaz, Gloria; BOSCOLO GALAZZO, Ilaria, Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer’s Disease Continuum «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , vol. 25 , n. 23 , 2024 , pp. 1-16

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo