Publications

Authors:

Galeone, Antonella; Annicchiarico, Alessia; Buccoliero, Cinzia; Barile, Barbara; Luciani, Giovanni Battista; Onorati, Francesco; Nicchia, Grazia Paola; Brunetti, Giacomina

Title:

Diabetic Cardiomyopathy: Role of Cell Death, Exosomes, Fibrosis and Epicardial Adipose Tissue

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN of journal:

1422-0067

N° Volume:

25

Number or Folder:

17

Page numbers:

1-14

Keyword:

diabetic cardiomyopathy; apoptosis; autophagy; pyroptosis; ferroptosis; fibrosis; exosomes

Short description of contents:

Diabetic cardiomyopathy (DCM) represents one of the typical complications associated with diabetes. It has been described as anomalies in heart function and structure, with consequent high morbidity and mortality. DCM development can be described by two stages; the first is characterized by left ventricular hypertrophy and diastolic dysfunction, and the second by heart failure (HF) with systolic dysfunction. The proposed mechanisms involve cardiac inflammation, advanced glycation end products (AGEs) and angiotensin II. Furthermore, different studies have focused their attention on cardiomyocyte death through the different mechanisms of programmed cell death, such as apoptosis, autophagy, necrosis, pyroptosis and ferroptosis. Exosome release, adipose epicardial tissue and aquaporins affect DCM development. This review will focus on the description of the mechanisms involved in DCM progression and development.

Product ID:

141311

Handle IRIS:

11562/1139447

Last Modified:

October 6, 2024

Bibliographic citation:

Galeone, Antonella; Annicchiarico, Alessia; Buccoliero, Cinzia; Barile, Barbara; Luciani, Giovanni Battista; Onorati, Francesco; Nicchia, Grazia Paola; Brunetti, Giacomina, Diabetic Cardiomyopathy: Role of Cell Death, Exosomes, Fibrosis and Epicardial Adipose Tissue «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , vol. 25 , n. 17 , 2024 , pp. 1-14

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