Publications

Authors:

Mattiolo, Paola; De Bellis, Mario; Mafficini, Andrea; Fassan, Matteo; Bevere, Michele; Ciulla, Calogero; Bersani, Samantha; Lawlor, Rita T; Milella, Michele; Scarpa, Aldo; Luchini, Claudio; Ruzzenente, Andrea

Title:

Long-Term Survivor of Intrahepatic Cholangiocarcinoma for over 18 Years: Case Study with Longitudinal Histo-molecular and Tumor Immune Microenvironment Characterization and Systematic Review of the Literature

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF GASTROINTESTINAL CANCER

ISSN of journal:

1941-6636

N° Volume:

55

Number or Folder:

4

Page numbers:

1634-1646

Keyword:

Biliary; Cholangiocarcinoma; Intrahepatic; Long survival; Long survivor; Relapse

Short description of contents:

Background: Intrahepatic cholangiocarcinoma is a biliary neoplasm usually showing a dismal prognosis. In early stages, surgical resection is the best treatment option, significantly increasing the overall survival. This approach is also recommended in the case of relapsing disease. In this study, we report the case of a patient affected by intrahepatic cholangiocarcinoma with multiple relapses and still alive for over 18 years. We also provide a systematic review regarding long-survivor (> 60 months) of intrahepatic cholangiocarcinoma. Case presentation: A 41-year-old woman with no pathological history was diagnosed with localized intrahepatic cholangiocarcinoma and surgically treated with left hepatectomy. After the first intervention, the patients underwent three further surgical resections because of locoregional recurrences. Histologically, there were some significant similarities among all neoplasms, including the tubule-glandular architecture, but also morphological heterogeneity. The tumor immune microenvironment remained stable across the different lesions. The molecular analysis with next-generation sequencing demonstrated that all neoplasms shared the same genomic profile, including NBN and NOTCH3 mutations and chromosomes 1 and 3 alterations. Conclusions: This case study highlights the essential role of a stringent follow-up after resection of intrahepatic cholangiocarcinoma for detecting early relapsing tumors. Moreover, it shows the importance of the molecular characterization of multiple tumors for understanding their real nature. The accurate study of long-surviving patients highlights the features that are critical for outcome improvement.

Note:

Paola Mattiolo, Mario De Bellis, and Andrea Mafficini have co-first authorship. Aldo Scarpa, Claudio Luchini, and Andrea Ruzzenente have co-last authorship. Epub 2024 Sep 16

Product ID:

141163

Handle IRIS:

11562/1137387

Last Modified:

November 22, 2024

Bibliographic citation:

Mattiolo, Paola; De Bellis, Mario; Mafficini, Andrea; Fassan, Matteo; Bevere, Michele; Ciulla, Calogero; Bersani, Samantha; Lawlor, Rita T; Milella, Michele; Scarpa, Aldo; Luchini, Claudio; Ruzzenente, Andrea, Long-Term Survivor of Intrahepatic Cholangiocarcinoma for over 18 Years: Case Study with Longitudinal Histo-molecular and Tumor Immune Microenvironment Characterization and Systematic Review of the Literature «JOURNAL OF GASTROINTESTINAL CANCER» , vol. 55 , n. 4 , 2024 , pp. 1634-1646

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