Publications

Authors:

Dolci, Giorgio; Cruciani, Federica; Brusini, Lorenza; Pini, Lorenzo; Galazzo, Ilaria Boscolo; Calhoun, Vince D.; Menegaz, Gloria

Title:

Diffusion MRI Allows Capturing the Amyloid-β and τ Proteins Status in Alzheimer’s Disease Continuum

Year:

2024

Type of item:

Contributo in atti di convegno

Tipologia ANVUR:

Contributo in Atti di convegno

Language:

Inglese

Congresso:

21st IEEE International Symposium on Biomedical Imaging

Place:

Athens

Period:

27 May 2024 through 30 May 2024

Page numbers:

1-5

Keyword:

Convolutional Neural Network; Integrated Gradient; Post-hoc Analysis

Short description of contents:

Alzheimer's Disease (AD) is a neurodegenerative process characterized by the accumulation of amyloid-β (Aβ) and tau (τ) proteins leading to neurodegeneration. It has been hypothesizes that the aggregation of these proteins could spread through specific white matter (WM) pathways. To investigate such hypothesis, convolutional neural networks were employed to analyze microstructural alterations induced by the accumulation of Aβ and τ proteins via two classification tasks, relying on mean diffusivity (MD) and fractional anisotropy (FA), achieving competitive performance. A post-hoc analysis via integrated gradients revealed that the splenium of the corpus callosum played a prominent role for both indices, while index-specific were the ventricles and subcortical regions for MD and the corticospinal tract for FA. This supports the assumption that WM pathways might play a key role in misfolded protein distribution and highlights the potential of diffusion imaging for the identification of Aβ and τ proteins spread and accumulation.

Product ID:

141151

Handle IRIS:

11562/1137326

Last Modified:

April 20, 2025

Bibliographic citation:

Dolci, Giorgio; Cruciani, Federica; Brusini, Lorenza; Pini, Lorenzo; Galazzo, Ilaria Boscolo; Calhoun, Vince D.; Menegaz, Gloria, Diffusion MRI Allows Capturing the Amyloid-β and τ Proteins Status in Alzheimer’s Disease Continuum  in Proceedings - International Symposium on Biomedical Imaging , Proceedings of "21st IEEE International Symposium on Biomedical Imaging" , Athens , 27 May 2024 through 30 May 2024 , 2024 , pp. 1-5

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo