Publications

Authors:

Notarte, Kin Israel; Carandang, Timothy Hudson David Culasino; Velasco, Jacqueline Veronica; Pastrana, Adriel; Ver, Abbygail Therese; Manalo, Gerald Neil; Ng, Jeremy Ace; Grecia, Steven; Lippi, Giuseppe; Henry, Brandon Michael; Fernández-de-Las-Peñas, César

Title:

Autoantibodies in COVID-19 survivors with post-COVID symptoms: a systematic review

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

FRONTIERS IN IMMUNOLOGY

ISSN of journal:

1664-3224

N° Volume:

15

Page numbers:

1428645-1428645

Keyword:

PASC, SARS-CoV-2 infection (COVID-19), autoantibodies, long COVID, post-COVID-19

Short description of contents:

Objective: The long-lasting persistence of autoantibodies stands as one of the hypotheses explaining the multisystemic manifestations seen in individuals with post-COVID-19 condition. The current review offers restricted insights into the persistence of autoantibodies in plasma/serum in people with post-COVID symptoms. Methods: PubMed/MEDLINE, CINAHL, EMBASE, and Web of Science databases, as well as on medRxiv and bioRxiv preprint servers were searched up to January 5th, 2024. Papers investigating the presence of autoantibodies in plasma/serum samples in people with post-COVID symptoms were included. The Newcastle-Ottawa Scale (NOS) was used to assess methodological quality. Results: From 162 identified records, five articles met all inclusion criteria; four studies included infected controls with no post-COVID symptoms whereas all five studies included non-infected controls (410 COVID-19 survivors with post-COVID symptoms, 223 COVID-19 survivors with no post-COVID symptoms as controls and 266 non-infected healthy controls). Four studies concluded that the presence of autoantibodies had a potential (but small) role in post-COVID-19 condition whereas one study concluded that autoantibodies were not associated. Quality assessment showed all studies had high methodological quality. Conclusion: Although evidence suggests that persistent autoantibodies can be associated with post-COVID symptoms, the clinical relevance of their presence seems modest at this stage. Current results highlight further research to clarify the role of autoantibodies in the development of post-COVID symptoms, guiding the development of tailored diagnostic and treatment approaches to enhance patient outcomes.

Web page:

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1428645/full

Product ID:

140592

Handle IRIS:

11562/1131808

Last Modified:

September 26, 2024

Bibliographic citation:

Notarte, Kin Israel; Carandang, Timothy Hudson David Culasino; Velasco, Jacqueline Veronica; Pastrana, Adriel; Ver, Abbygail Therese; Manalo, Gerald Neil; Ng, Jeremy Ace; Grecia, Steven; Lippi, Giuseppe; Henry, Brandon Michael; Fernández-de-Las-Peñas, César, Autoantibodies in COVID-19 survivors with post-COVID symptoms: a systematic review «FRONTIERS IN IMMUNOLOGY» , vol. 15 , 2024 , pp. 1428645-1428645

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo