Publications

Authors:

Catalano, Fabio; Brunelli, Matteo; Signori, Alessio; Rescigno, Pasquale; Buti, Sebastiano; Galli, Luca; Spada, Massimiliano; Masini, Cristina; Galuppini, Francesca; Vellone, Valerio Gaetano; Gaggero, Gabriele; Maruzzo, Marco; Merler, Sara; Vignani, Francesca; Cavo, Alessia; Bimbatti, Davide; Milella, Michele; Dei Tos, Angelo Paolo; Sbaraglia, Marta; Murianni, Veronica; Damassi, Alessandra; Cremante, Malvina; Maffezzoli, Michele; Llaja Obispo, Miguel Angel; Banna, Giuseppe Luigi; Fornarini, Giuseppe; Rebuzzi, Sara Elena

Title:

Analyses of tumor microenvironment in patients with advanced renal cell carcinoma receiving immunotherapy (Meet-URO 18 study)

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

FUTURE ONCOLOGY

ISSN of journal:

1744-8301

N° Volume:

20

Number or Folder:

21

Page numbers:

1495-1503

Keyword:

CD4; CD56; CD8; PD-L1; immune checkpoint inhibitor; immunotherapy; renal cell carcinoma; tumor microenvironment

Short description of contents:

: Introduction: The Meet-URO 18 study is a multicentric study of patients with metastatic renal cell carcinoma receiving nivolumab in the second-line and beyond, categorized as responders (progression-free survival ≥ 12 months) and non-responders (progression-free survival < 3 months). Areas covered: The current study includes extensive immunohistochemical analysis of T-lineage markers (CD3, CD4, CD8, CD8/CD4 ratio), macrophages (CD68), ph-mTOR, CD15 and CD56 expression on tumor cells, and PD-L1 expression, on an increased sample size including 161 tumor samples (113 patients) compared with preliminary presented data. Responders' tumor tissue (n = 90; 55.9%) was associated with lower CD4 expression (p = 0.014), higher CD56 expression (p = 0.046) and higher CD8/CD4 ratio (p = 0.030). Expert opinion/commentary: The present work suggests the regulatory role of a subpopulation of T cells on antitumor response and identifies CD56 as a putative biomarker of immunotherapy efficacy.

Product ID:

140092

Handle IRIS:

11562/1128687

Last Modified:

October 2, 2024

Bibliographic citation:

Catalano, Fabio; Brunelli, Matteo; Signori, Alessio; Rescigno, Pasquale; Buti, Sebastiano; Galli, Luca; Spada, Massimiliano; Masini, Cristina; Galuppini, Francesca; Vellone, Valerio Gaetano; Gaggero, Gabriele; Maruzzo, Marco; Merler, Sara; Vignani, Francesca; Cavo, Alessia; Bimbatti, Davide; Milella, Michele; Dei Tos, Angelo Paolo; Sbaraglia, Marta; Murianni, Veronica; Damassi, Alessandra; Cremante, Malvina; Maffezzoli, Michele; Llaja Obispo, Miguel Angel; Banna, Giuseppe Luigi; Fornarini, Giuseppe; Rebuzzi, Sara Elena, Analyses of tumor microenvironment in patients with advanced renal cell carcinoma receiving immunotherapy (Meet-URO 18 study) «FUTURE ONCOLOGY» , vol. 20 , n. 21 , 2024 , pp. 1495-1503

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo