Publications

Authors:

Chiappella, Annalisa; Casadei, Beatrice; Chiusolo, Patrizia; Di Rocco, Alice; Ljevar, Silva; Magni, Martina; Angelillo, Piera; Barbui, Anna Maria; Cutini, Ilaria; Dodero, Anna; Bonifazi, Francesca; Tisi, Maria Chiara; Bramanti, Stefania; Musso, Maurizio; Farina, Mirko; Martino, Massimo; Novo, Mattia; Grillo, Giovanni; Patriarca, Francesca; Zacchi, Giulia; Krampera, Mauro; Pennisi, Martina; Galli, Eugenio; Martelli, Maurizio; Ferreri, Andrés J M; Ferrari, Silvia; Saccardi, Riccardo; Bermema, Anisa; Guidetti, Anna; Miceli, Rosalba; Zinzani, Pier Luigi; Corradini, Paolo

Title:

Axicabtagene ciloleucel treatment is more effective in primary mediastinal large B-cell lymphomas than in diffuse large B-cell lymphomas: the Italian CART-SIE study

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Leukemia

ISSN of journal:

0887-6924

N° Volume:

38

Number or Folder:

5

Page numbers:

1107-1114

Keyword:

CAR T

Short description of contents:

Axicabtagene ciloleucel showed efficacy for relapsed/refractory large B-cell lymphomas (LBCL), including primary mediastinal B-cell lymphomas (PMBCL); however, only few PMBCLs were reported. Aim was to evaluate efficacy and safety of axicabtagene ciloleucel in patients with PMBCL compared to those with other LBCL, enrolled in the Italian prospective observational CART-SIE study. PMBCLs (n = 70) were younger, with higher percentage of bulky and refractory disease, compared to other LBCLs (n = 190). Median follow-up time for infused patients was 12.17 months (IQR 5.53,22.73). The overall (complete + partial) response rate (ORR,CR + PR) after bridging was 41% for PMBCL and 28% for other LBCL, p = 0.0102. Thirty days ORR was 78% (53/68) with 50% (34) CR in PMBCL, and 75% (141/187) with 53% (100) CR in other LBCL, p = 0.5457. Ninety days ORR was 69% (45/65) with 65% (42) CR in PMBCL, and 54% (87/162) with 47% (76) CR in other LBCL; progressive disease was 21% in PMBCL and 45% in other LBCL, p = 0.0336. Twelve months progression-free survival was 62% (95% CI: 51-75) in PMBCL versus 48% (95% CI: 41-57) in other LBCL, p = 0.0386. Twelve months overall survival was 86% (95% CI: 78-95) in PMBCL versus 71% (95% CI: 64-79) in other LBCL, p = 0.0034. All grade cytokine release syndrome was 88% (228/260); all grade neurotoxicity was 34% (88/260), with 6% of fatal events in PMBCL. Non-relapse mortality was 3%. In conclusion, PMBCLs achieved significantly better response and survival rates than other LBCLs.

Product ID:

139545

Handle IRIS:

11562/1126175

Last Modified:

October 6, 2024

Bibliographic citation:

Chiappella, Annalisa; Casadei, Beatrice; Chiusolo, Patrizia; Di Rocco, Alice; Ljevar, Silva; Magni, Martina; Angelillo, Piera; Barbui, Anna Maria; Cutini, Ilaria; Dodero, Anna; Bonifazi, Francesca; Tisi, Maria Chiara; Bramanti, Stefania; Musso, Maurizio; Farina, Mirko; Martino, Massimo; Novo, Mattia; Grillo, Giovanni; Patriarca, Francesca; Zacchi, Giulia; Krampera, Mauro; Pennisi, Martina; Galli, Eugenio; Martelli, Maurizio; Ferreri, Andrés J M; Ferrari, Silvia; Saccardi, Riccardo; Bermema, Anisa; Guidetti, Anna; Miceli, Rosalba; Zinzani, Pier Luigi; Corradini, Paolo, Axicabtagene ciloleucel treatment is more effective in primary mediastinal large B-cell lymphomas than in diffuse large B-cell lymphomas: the Italian CART-SIE study «Leukemia» , vol. 38 , n. 5 , 2024 , pp. 1107-1114

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