Publications

Authors:

Greaves, Lauren M; Zaleski, Kendall S; Matias, Alexs A; Gyampo, Abena O; Giuriato, Gaia; Lynch, Meaghan; Lora, Brian; Tomasi, Tawn; Basso, Emma; Finegan, Emma; Schickler, Jack; Venturelli, Massimo; Deblauw, Justin A; Shostak, Elena; Blum, Oliver E; Ives, Stephen J

Title:

Limb, sex, but not acute dietary capsaicin, modulate the near-infrared spectroscopy-vascular occlusion test estimate of muscle metabolism

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

PHYSIOLOGICAL REPORTS

ISSN of journal:

2051-817X

N° Volume:

12

Number or Folder:

6

Page numbers:

1-12

Keyword:

desaturation rate; mitochondria; muscle VO2; sex differences; slope 1; vascular occlusion test

Short description of contents:

The downward slope during the near-infrared spectroscopy (NIRS)-vascular occlusion test (NIRS-VOT) is purported as a simplified estimate of metabolism. Whether or not the NIRS-VOT exhibits sex- or limb-specificity or may be acutely altered remains to be elucidated. Thus, we investigated if there is limb- or sex specificity in tissue desaturation rates (DeO2) during a NIRS-VOT, and if acute dietary capsaicin may alter this estimate of muscle metabolism. Young healthy men (n = 25, 21 ± 4 years) and women (n = 20, 20 ± 1 years) ingested either placebo or capsaicin, in a counterbalanced, single-blind, crossover design after which a simplified NIRS-VOT was conducted to determine the DeO2 (%/s), as an estimate of oxidative muscle metabolism, in both the forearm (flexors) and thigh (vastus lateralis). There was a significant limb effect with the quadriceps having a greater DeO2 than the forearm (-2.31 ± 1.34 vs. -1.78 ± 1.22%/s, p = 0.007, ηp 2 = 0.19). There was a significant effect of sex on DeO2 (p = 0.005, ηp 2 = 0.203) with men exhibiting a lesser DeO2 than women (-1.73 ± 1.03 vs. -2.36 ± 1.32%/s, respectively). This manifested in significant interactions of limb*capsaicin (p = 0.001, ηp 2 = 0.26) as well as limb*capsaicin*sex on DeO2 (p = 0.013, ηp 2 = 0.16) being observed. Capsaicin does not clearly alter O2-dependent muscle metabolism, but there was apparent limb and sex specificity, interacting with capsaicin in this NIRS-derived assessment.

Web page:

https://doi.org/10.14814/phy2.15988

Product ID:

138849

Handle IRIS:

11562/1123589

Last Modified:

May 31, 2024

Bibliographic citation:

Greaves, Lauren M; Zaleski, Kendall S; Matias, Alexs A; Gyampo, Abena O; Giuriato, Gaia; Lynch, Meaghan; Lora, Brian; Tomasi, Tawn; Basso, Emma; Finegan, Emma; Schickler, Jack; Venturelli, Massimo; Deblauw, Justin A; Shostak, Elena; Blum, Oliver E; Ives, Stephen J, Limb, sex, but not acute dietary capsaicin, modulate the near-infrared spectroscopy-vascular occlusion test estimate of muscle metabolism «PHYSIOLOGICAL REPORTS» , vol. 12 , n. 6 , 2024 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo