Publications

Authors:

Galeone, Antonella; Buccoliero, Cinzia; Barile, Barbara; Paola Nicchia, Grazia; Onorati, Francesco; Luciani, GIOVANNI BATTISTA; Brunetti, Giacomina

Title:

Cellular and Molecular Mechanisms Activated by a Left Ventricular Assist Device

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN of journal:

1422-0067

Page numbers:

1-21

Keyword:

LVAD; inflammation; von Willebrand disease; malnutrition

Short description of contents:

Left ventricular assist devices (LVADs) represent the final treatment for patients with end-stage heart failure (HF) not eligible for transplantation. Although LVAD design has been further improved in the last decade, their use is associated with different complications. Specifically, inflammation, fibrosis, bleeding events, right ventricular failure, and aortic valve regurgitation may occur. In addition, reverse remodeling is associated with substantial cellular and molecular changes of the failing myocardium during LVAD support with positive effects on patients’ health. All these processes also lead to the identification of biomarkers identifying LVAD patients as having an augmented risk of developing associated adverse events, thus highlighting the possibility of identifying new therapeutic targets. Additionally, it has been reported that LVAD complications could cause or exacerbate a state of malnutrition, suggesting that, with an adjustment in nutrition, the general health of these patients could be improved.

Product ID:

136806

Handle IRIS:

11562/1116207

Last Modified:

April 5, 2024

Bibliographic citation:

Galeone, Antonella; Buccoliero, Cinzia; Barile, Barbara; Paola Nicchia, Grazia; Onorati, Francesco; Luciani, GIOVANNI BATTISTA; Brunetti, Giacomina, Cellular and Molecular Mechanisms Activated by a Left Ventricular Assist Device «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , 2024 , pp. 1-21

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