Publications

Authors:

Siviero, Ilaria; Bonfanti, Davide; Menegaz, Gloria; Savazzi, Silvia; Mazzi, Chiara; Storti, Silvia Francesca

Title:

Graph analysis of TMS–EEG connectivity reveals hemispheric differences following occipital stimulation

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

SENSORS

ISSN of journal:

1424-8220

N° Volume:

23

Number or Folder:

21

Page numbers:

1-21

Keyword:

TMS-EEG; Occipital stimulation; TEP; Brain functional connectivity; Graph analysis

Short description of contents:

(1) Background: Transcranial magnetic stimulation combined with electroencephalography (TMS–EEG) provides a unique opportunity to investigate brain connectivity. However, possible hemispheric asymmetries in signal propagation dynamics following occipital TMS have not been investigated. (2) Methods: Eighteen healthy participants underwent occipital single-pulse TMS at two different EEG sites, corresponding to early visual areas. We used a state-of-the-art Bayesian estimation approach to accurately estimate TMS-evoked potentials (TEPs) from EEG data, which has not been previously used in this context. To capture the rapid dynamics of information flow patterns, we implemented a self-tuning optimized Kalman (STOK) filter in conjunction with the information partial directed coherence (iPDC) measure, enabling us to derive time-varying connectivity matrices. Subsequently, graph analysis was conducted to assess key network properties, providing insight into the overall network organization of the brain network. (3) Results: Our findings revealed distinct lateralized effects on effective brain connectivity and graph networks after TMS stimulation, with left stimulation facilitating enhanced communication between contralateral frontal regions and right stimulation promoting increased intra-hemispheric ipsilateral connectivity, as evidenced by statistical test (p < 0.001). (4) Conclusions: The identified hemispheric differences in terms of connectivity provide novel insights into brain networks involved in visual information processing, revealing the hemispheric specificity of neural responses to occipital stimulation.

Web page:

https://doi.org/10.3390/s23218833

Product ID:

136162

Handle IRIS:

11562/1112907

Last Modified:

January 30, 2025

Bibliographic citation:

Siviero, Ilaria; Bonfanti, Davide; Menegaz, Gloria; Savazzi, Silvia; Mazzi, Chiara; Storti, Silvia Francesca, Graph analysis of TMS–EEG connectivity reveals hemispheric differences following occipital stimulation «SENSORS» , vol. 23 , n. 21 , 2023 , pp. 1-21

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