Publications

Authors:

Perrone, Fabiana; Belluomini, Lorenzo; Mazzotta, Marco; Bianconi, Maristella; Di Noia, Vincenzo; Meacci, Fiammetta; Montrone, Michele; Pignataro, Daniele; Prelaj, Arsela; Rinaldi, Silvia; Russano, Marco; Sartori, Giulia; Bironzo, Paolo; Facchinetti, Francesco; Menis, Jessica; Tiseo, Marcello; Galetta, Domenico; Novello, Silvia; Pilotto, Sara

Title:

Exploring the role of respiratory microbiome in lung cancer: A systematic review

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Critical Review in Oncology/Hematology

ISSN of journal:

1040-8428

N° Volume:

164

Page numbers:

103404--

Keyword:

Lung cancer; Lung microbiota; Prognosis

Short description of contents:

Giving the potential contribute in cancer initiation and progression, lung microbiota represents a promising topic in cancer research, although still unexplored. We performed a systematic literature search to identify clinical studies evaluating lung microbiota composition, its correlation with lung cancer patients' clinico-pathological features and prognosis. Of the identified 370 studies, 21 were eligible and included. Although studies were heterogeneous, lung cancer resulted to be enriched in peculiar microbial communities, with differences in composition and diversity according to clinico-pathological parameters. Few studies explored how lung microbiota influences cancer outcome. In light of these findings and borrowing the suggestions coming from gut microbiota, we speculate that respiratory microbiome may influence pathogenesis, progression and outcome of lung cancer. Taking advantage of the experience of chronical lung diseases, prospective studies should be designed to evaluate lung microbiota changes throughout any phase of lung cancer course, particularly with the advent of immunotherapy as pivotal treatment.

Product ID:

133967

Handle IRIS:

11562/1094607

Last Modified:

May 28, 2023

Bibliographic citation:

Perrone, Fabiana; Belluomini, Lorenzo; Mazzotta, Marco; Bianconi, Maristella; Di Noia, Vincenzo; Meacci, Fiammetta; Montrone, Michele; Pignataro, Daniele; Prelaj, Arsela; Rinaldi, Silvia; Russano, Marco; Sartori, Giulia; Bironzo, Paolo; Facchinetti, Francesco; Menis, Jessica; Tiseo, Marcello; Galetta, Domenico; Novello, Silvia; Pilotto, Sara, Exploring the role of respiratory microbiome in lung cancer: A systematic review «Critical Review in Oncology/Hematology» , vol. 164 , 2021 , pp. 103404--

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo