Publications

Authors:

Belluomini, Lorenzo; Avancini, Alice; Sposito, Marco; Milella, Michele; Rossi, Antonio; Pilotto, Sara

Title:

Antibody-drug conjugates (ADCs) targeting TROP-2 in lung cancer

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

EXPERT OPINION ON BIOLOGICAL THERAPY

ISSN of journal:

1471-2598

N° Volume:

23

Number or Folder:

11

:

Ashley Publications Limited:Unitec House, Third Floor, 2 Albert Place, Finchley Central, London N3 1QB United Kingdom:011 44 208 3433883, EMAIL: jdrake@ashley-pub.com, INTERNET: http://www.ashley-pub.com, Fax: 011 44 208 3432313

Page numbers:

1077-1087

Keyword:

ADCs; TROP-2; datopotamab deruxtecan; non-small cell lung cancer; sacituzumab govitecan; small cell lung cancer

Short description of contents:

Introduction: The advent of antibody-drug conjugates (ADCs) represents a renewed strategy in the era of precision oncology. Several epithelial tumors harbor overexpression of the trophoblast cell-surface antigen 2 (TROP-2), which represents a predictor of poor prognosis and a promising target for anticancer therapy. Areas covered: In this review, we aim to collect the available preclinical and clinical data regarding anti-TROP-2 ADCs in lung cancer obtained through extensive literature research and screening of the available abstract/posters presented at recent meetings. Expert opinion: Anti-TROP-2 ADCs represent an innovative upcoming weapon against both non-small cell lung cancer and small cell lung cancer subtypes, pending the results of several ongoing trials. The proper combination and placement of this agent throughout the lung cancer treatment pathway, the identification of potentially predictive biomarkers of benefit, as well as the optimal management and impact of peculiar toxicity (i.e. interstitial lung disease) are the next questions to be answered.

Web page:

https://doi.org/10.1080/14712598.2023.2198087

Product ID:

133378

Handle IRIS:

11562/1092346

Last Modified:

December 29, 2023

Bibliographic citation:

Belluomini, Lorenzo; Avancini, Alice; Sposito, Marco; Milella, Michele; Rossi, Antonio; Pilotto, Sara, Antibody-drug conjugates (ADCs) targeting TROP-2 in lung cancer «EXPERT OPINION ON BIOLOGICAL THERAPY» , vol. 23 , n. 11 , 2023 , pp. 1077-1087

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo