Publications

Authors:

Dreyer, Stephan B; Rae, Sarah; Bisset, Kirsty; Upstill-Goddard, Rosie; Gemenetzis, Georgios; Johns, Amber L; Dickson, Euan J; Mittal, Anubhav; Gill, Anthony J; Duthie, Fraser; Pea, Antonio; Lawlor, Rita T; Scarpa, Aldo; Salvia, Roberto; Pulvirenti, Alessandra; Zerbi, Alessandro; Marchesi, Federica; Mckay, Colin J; Biankin, Andrew V; Samra, Jaswinder S; Chang, David K; Jamieson, Nigel B

Title:

The Impact of Molecular Subtyping on Pathological Staging of Pancreatic Cancer

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

Annals of Surgery

ISSN of journal:

0003-4932

N° Volume:

277

Number or Folder:

2

Page numbers:

396-405

Keyword:

cancer staging, molecular subtyping, pancreatic cancer

Short description of contents:

Background: The long-term outcomes following surgical resection for pancreatic ductal adenocarcinoma (PDAC) remains poor, with only 20% of patients surviving 5 years after pancreatectomy. Patient selection for surgery remains suboptimal largely due to the absence of consideration of aggressive tumor biology. Objective: The aim of this study was to evaluate traditional staging criteria for PDAC in the setting of molecular subtypes. Methods: Clinicopathological data were obtained for 5 independent cohorts of consecutive unselected patients, totaling n = 1298, including n = 442 that underwent molecular subtyping. The main outcome measure was disease-specific survival following surgical resection for PDAC stratified according to the American Joint Commission for Cancer (TNM) staging criteria, margin status, and molecular subtype. Results: TNM staging criteria and margin status confers prognostic value only in tumors with classical pancreatic subtype. Patients with tumors that are of squamous subtype, have a poor outcome irrespective of favorable traditional pathological staging [hazard ratio (HR) 1.54, 95% confidence interval (CI) 1.04-2.28, P = 0.032]. Margin status has no impact on survival in the squamous subtype (16.0 vs 12.1 months, P = 0.374). There were no differences in molecular subtype or gene expression of tumors with positive resection margin status. Conclusions: Aggressive tumor biology as measured by molecular subtype predicts poor outcome following pancreatectomy for PDAC and should be utilized to inform patient selection for surgery.

Product ID:

131692

Handle IRIS:

11562/1084727

Last Modified:

March 28, 2023

Bibliographic citation:

Dreyer, Stephan B; Rae, Sarah; Bisset, Kirsty; Upstill-Goddard, Rosie; Gemenetzis, Georgios; Johns, Amber L; Dickson, Euan J; Mittal, Anubhav; Gill, Anthony J; Duthie, Fraser; Pea, Antonio; Lawlor, Rita T; Scarpa, Aldo; Salvia, Roberto; Pulvirenti, Alessandra; Zerbi, Alessandro; Marchesi, Federica; Mckay, Colin J; Biankin, Andrew V; Samra, Jaswinder S; Chang, David K; Jamieson, Nigel B, The Impact of Molecular Subtyping on Pathological Staging of Pancreatic Cancer «Annals of Surgery» , vol. 277 , n. 2 , 2023 , pp. 396-405

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