Publications

Authors:

Recchiuti, Antonio; Federti, Enrica; Matte', Alessandro; Mazzi, Filippo; Ceolan, Jacopo; Porreca, Annamaria; Di Nicola, Marta; Menotti, Sofia; Alivernini, Stefano; DE FRANCESCHI, Lucia

Title:

Impaired pro‐resolving mechanisms promote abnormal NETosis , fueling autoimmunity in sickle cell disease

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

American Journal of Hematology

ISSN of journal:

0361-8609

N° Volume:

98

Number or Folder:

3

Page numbers:

E45-E48

Keyword:

neptosis, sickle cell disease, immunity

Short description of contents:

Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorders with still high mortality and morbidity and limited therapeutic options. SCD is characterized by anemia, chronic hemolysis, and acute vaso-occlusive painful crises. The biocomplexity of SCD goes beyond red cells, involving neutrophils and soluble factors such as cytokines or alternative complement pathway intensively cross-talking with vascular endothelial cells. In addition, in SCD, the overactivation of neutrophils contributes to the production of neutrophil extracellular traps (NETs) (1, 2). This might trigger endothelial vascular injury, promoting acute sickle cell related events and increasing the risk of infections in patients with SCD

Product ID:

133163

Handle IRIS:

11562/1090250

Last Modified:

October 30, 2024

Bibliographic citation:

Recchiuti, Antonio; Federti, Enrica; Matte', Alessandro; Mazzi, Filippo; Ceolan, Jacopo; Porreca, Annamaria; Di Nicola, Marta; Menotti, Sofia; Alivernini, Stefano; DE FRANCESCHI, Lucia, Impaired pro‐resolving mechanisms promote abnormal NETosis , fueling autoimmunity in sickle cell disease «American Journal of Hematology» , vol. 98 , n. 3 , 2023 , pp. E45-E48

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