Pubblicazioni

Autori:

Gigliotti, C. R.; Altabella, L.; Boschi, Federico; Spinelli, A. E.

Titolo:

Monte Carlo feasibility study for image guided surgery: from direct beta minus detection to Cerenkov luminescence imaging

Anno:

2016

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

JOURNAL OF INSTRUMENTATION

ISSN Rivista:

1748-0221

N° Volume:

11

Numero o Fascicolo:

07

Intervallo pagine:

P07021-P07021

Parole chiave:

Intra-operative probes; Multi-modality systems

Breve descrizione dei contenuti:

The goal of this work is to compare the performances of different beta minus detection strategies for image guided surgery or ex vivo tissue analysis. In particular we investigated Cerenkov luminescence imaging (CLI) with and without the use of a radiator, direct and indirect beta detection and bremsstrahlung imaging using beta emitters commonly employed in Nuclear Medicine. Monte Carlo simulations were implemented using the GAMOS plug-in for GEANT4 considering a slab of muscle and a radioactive source (32P or 90Y) placed at 0.5 mm depth. We estimated the gain that can be obtained in terms of produced photons using different materials placed on the slab used as Cerenkov radiators, we then focused on the number of exiting photons and their spatial distribution for the different strategies. The use of radiator to enhance Cerenkov signal reduces the spatial resolution because of the increased optical spread. We found that direct beta detection and CLI are best approaches in term of resolution while the use of a thin scintillator increases the signal but the spatial resolution is degraded. Bremsstrahlung presents lower signal and it does not represent the best choice for image guided surgery. CLI represents a more flexible approach for image guided surgery using or ex vivo tissue analysis using beta-emitter imaging.

Id prodotto:

98399

Handle IRIS:

11562/966159

ultima modifica:

28 marzo 2023

Citazione bibliografica:

Gigliotti, C. R.; Altabella, L.; Boschi, Federico; Spinelli, A. E., Monte Carlo feasibility study for image guided surgery: from direct beta minus detection to Cerenkov luminescence imaging «JOURNAL OF INSTRUMENTATION» , vol. 11 , n. 07 , 2016 , pp. P07021-P07021

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