Pubblicazioni

Autori:

Tamellini, E; Simio, C; Bernardelli, A; Ferrarini, I; Vatteroni, A; Moioli, A; Macaluso, V; Marchetti, E; Tanasi, I

Titolo:

Successful rechallenge with azacytidine and venetoclax after sustained treatment-free remission in a relapsed acute myeloid leukemia patient: a case report

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Annals of Hematology

ISSN Rivista:

0939-5555

Intervallo pagine:

1-3

Parole chiave:

Acute myeloid leukemia; Azacytidine; Rechallenge; Retreatment; Treatment-free remission; Venetoclax

Breve descrizione dei contenuti:

Combined therapy with venetoclax and hypomethylating agents has significantly improved the outcome of unfit patients ineligible for intensive chemotherapy. A recently published exploratory analysis of the VIALE-A trial reported that up to 51% of patients achieving remission survived more than 2 years. These data along with those from reallife settings, lead to questioning how long it is appropriate to continue treatment in long-term survivors. Accordingly, recent retrospective studies suggested the feasibility of suspending therapy in selected patients while maintaining prolonged responses. Also, these studies showed that retreatment may induce a second remission in almost a third of patients. We report the case of a patient who received salvage therapy with venetoclax and azacytidine, that was discontinued few cycles after blasts clearance because of severe hematological toxicity. Despite suspension, he maintained a sustained response lasting almost one year and was successfully retreated with the same combination when a second relapse occurred.

Id prodotto:

141585

Handle IRIS:

11562/1141707

ultima modifica:

31 ottobre 2024

Citazione bibliografica:

Tamellini, E; Simio, C; Bernardelli, A; Ferrarini, I; Vatteroni, A; Moioli, A; Macaluso, V; Marchetti, E; Tanasi, I, Successful rechallenge with azacytidine and venetoclax after sustained treatment-free remission in a relapsed acute myeloid leukemia patient: a case report «Annals of Hematology » , 2024 , pp. 1-3

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