Pubblicazioni

Autori:

Dalbeni, Andrea; Natola, Leonardo Antonio; Garbin, Marta; Zoncapè, Mirko; Cattazzo, Filippo; Mantovani, Anna; Vella, Antonio; Canè, Stefania; Kassem, Jasmin; Bevilacqua, Michele; Conci, Simone; Campagnaro, Tommaso; Ruzzenente, Andrea; Auriemma, Alessandra; Drudi, Alessandro; Zanoni, Giovanna; Guglielmi, Alfredo; Milella, Michele; Sacerdoti, David

Titolo:

Interleukin-6: A New Marker of Advanced-Sarcopenic HCC Cirrhotic Patients

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

CANCERS

ISSN Rivista:

2072-6694

N° Volume:

15

Numero o Fascicolo:

9

Intervallo pagine:

1-12

Parole chiave:

Child-Pugh score; hepatocellular carcinoma; interleukin 6; sarcopenia

Breve descrizione dei contenuti:

Hepatocellular carcinoma (HCC) is the major cause of liver-related death worldwide. Interleukin 6 (IL-6) promotes the growth of the HCC microenvironment. The correlation between Child-Pugh (CP) and HCC stage and between HCC stage and sarcopenia is still not clear. Our aim was to investigate whether IL-6 is correlated with HCC stage and could represent a diagnostic marker for sarcopenia. Ninety-three HCC cirrhotic patients in different stages, according to BCLC-2022 (stages A, B, and C), were enrolled. Anthropometric and biochemical parameters, comprehensive of IL-6, were collected. The skeletal muscle index (SMI) was measured using dedicated software on computer tomography (CT) images. IL-6 level was higher in advanced (BCLC C) compared to the early-intermediate (BCLC A-B) stages (21.4 vs. 7.7 pg/mL, p < 0.005). On multivariate analysis, IL-6 levels were statistically dependent on the degree of liver disease severity (CP score) and HCC stages (p = 0.001 and p = 0.044, respectively). Sarcopenic patients presented lower BMI (24.7 +/- 5.3 vs. 28.5 +/- 7.0), higher PMN/lymphocyte ratio (2.9 +/- 2.4 vs. 2.3 +/- 1.2) and increased values of log (IL-6) (1.3 +/- 0.6 vs. 1.1 +/- 0.3). Univariate logistic regression between sarcopenia and log (IL-6) showed a significant odds ratio (OR 14.88, p = 0.044) with an AUC of 0.72. IL-6 appears to be an effective biomarker for the diagnosis of advanced cirrhotic HCC. In addition, IL-6 could be considered a marker of cirrhotic HCC-related sarcopenia, suggesting further investigation with BIA- or CT-dedicated software.

Note:

The page range is based on the pdf file available in the journal website

Id prodotto:

134343

Handle IRIS:

11562/1096526

ultima modifica:

10 maggio 2024

Citazione bibliografica:

Dalbeni, Andrea; Natola, Leonardo Antonio; Garbin, Marta; Zoncapè, Mirko; Cattazzo, Filippo; Mantovani, Anna; Vella, Antonio; Canè, Stefania; Kassem, Jasmin; Bevilacqua, Michele; Conci, Simone; Campagnaro, Tommaso; Ruzzenente, Andrea; Auriemma, Alessandra; Drudi, Alessandro; Zanoni, Giovanna; Guglielmi, Alfredo; Milella, Michele; Sacerdoti, David, Interleukin-6: A New Marker of Advanced-Sarcopenic HCC Cirrhotic Patients «CANCERS» , vol. 15 , n. 9 , 2023 , pp. 1-12

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo