Pubblicazioni

Autori:

Melisi, Davide; Cavaliere, Alessandro; Gobbo, Stefano; Fasoli, Giulia; Allegrini, Valentina; Simionato, Francesca; Gaule, Marina; Casalino, Simona; Pesoni, Camilla; Zecchetto, Camilla; Merz, Valeria; Mambrini, Andrea; Barbi, Emilio; Girelli, Roberto; Giardino, Alessandro; Frigerio, Isabella; Scalamogna, Roberto; Avitabile, Arianna; Castellani, Silvia; Milella, Michele; Butturini, Giovanni

Titolo:

Role of next-generation genomic sequencing in targeted agents repositioning for pancreaticoduodenal cancer patients

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Pancreatology

ISSN Rivista:

1424-3903

Intervallo pagine:

1-8

Parole chiave:

BRAF kinases; Next-generation sequencing; Precision medicine; RAF kinases; Sorafenib

Breve descrizione dei contenuti:

BACKGROUND: Pancreaticoduodenal cancer (PDC) is a group of malignant tumors arising in the ampullary region, which lack approved targeted therapies for their treatment.METHODS: This retrospective, observational study is based on Secondary Data Use (SDU) previously collected during a multicenter collaboration, which were subsequently entered into a predefined database and analyzed. FoundationOne CDx or Liquid, a next-generation DNA sequencing (NGS) service, was used to identify genomic alterations of patients who failed standard treatments. Detected alterations were described according to ESMO Scale of Clinical Actionability for molecular Targets (ESCAT).RESULTS: NGS analysis was performed in 68 patients affected by PDC. At least one alteration ranking tier I, II, III, or IV according to ESCAT classification was detected in 8, 1, 9, and 12 patients respectively (44.1%). Ten of them (33.3%) received a matched therapy. Patients with ESCAT tier I to IV were generally younger than the overall population (median=54, range=26-71 years), had an EGOG performance status score=0 (83.3%), and an uncommon histological or clinical presentation. The most common mutations with clinical evidence of actionability (ESCAT tier I-III) involved genes of the RAF (10.3%), BRCA (5.9%) or FGFR pathways (5.9%). We present the activity of the RAF kinases inhibitor sorafenib in patients with RAF-mutated advanced PDC.CONCLUSIONS: In advanced PDC, NGS is a feasible and valuable method for enabling precision oncology. This genomic profiling method might be considered after standard treatments failure, especially in young patients maintaining a good performance status, in order to detect potentially actionable mutations and offer molecularly targeted therapeutic approaches.

Id prodotto:

121333

Handle IRIS:

11562/1044675

ultima modifica:

28 marzo 2023

Citazione bibliografica:

Melisi, Davide; Cavaliere, Alessandro; Gobbo, Stefano; Fasoli, Giulia; Allegrini, Valentina; Simionato, Francesca; Gaule, Marina; Casalino, Simona; Pesoni, Camilla; Zecchetto, Camilla; Merz, Valeria; Mambrini, Andrea; Barbi, Emilio; Girelli, Roberto; Giardino, Alessandro; Frigerio, Isabella; Scalamogna, Roberto; Avitabile, Arianna; Castellani, Silvia; Milella, Michele; Butturini, Giovanni, Role of next-generation genomic sequencing in targeted agents repositioning for pancreaticoduodenal cancer patients «Pancreatology» , 2021 , pp. 1-8

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